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Circulating cell-fr...
Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey
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- Kananen, L (författare)
- Karolinska Institutet
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Hurme, M (författare)
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Jylna, M (författare)
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Harkaen, T (författare)
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Koskinen, S (författare)
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Stenholm, S (författare)
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Kahoen, M (författare)
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Lehtimaki, T (författare)
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Ukkola, O (författare)
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- Jylhava, J (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-08-14
- 2020
- Engelska.
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1, s. 13809-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Increased levels of circulating cell-free DNA (cf-DNA) are associated with and predict poor health outcomes. However, its predictive ability for mortality in population-based samples remains understudied. We analysed the capability of cf-DNA to predict all-cause mortality and assessed whether it adds predictive value on top of the other risk factors in the Health 2000 survey (n = 1,257, 46–76 years of age, 15-years-follow-up, 18% deceased). When analysed in a multivariate model with the other factors that independently predicted mortality in the sample (age, gender, self-rated health, smoking and plasma levels of glucose and adiponectin), increases in cf-DNA levels were associated with increased risk of mortality (hazard ratio [HR] for 0.1 µg increase in cf-DNA: 1.017, 95% confidence interval [CI] 1.008–1.026, p = 0.0003). Inclusion of cf-DNA in the model improved the model fit and discrimination. Stratifying the analysis by cardiovascular disease (CVD) status indicated that cf-DNA predicted mortality equally well in individuals with (HR 1.018, 95% CI 1.008–1.026, p = 0.002) and without (HR 1.018, 95% CI 1.001–1.035, p = 0.033) CVD. In conclusion, our study indicates that cf-DNA level predicts mortality in middle-aged and older individuals, also among those with established CVD, and adds significant value to mortality prediction. Our results thus underscore the role of cf-DNA as a viable marker of health.
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Kananen, L
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Hurme, M
-
Jylna, M
-
Harkaen, T
-
Koskinen, S
-
Stenholm, S
-
visa fler...
-
Kahoen, M
-
Lehtimaki, T
-
Ukkola, O
-
Jylhava, J
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visa färre...
- Artiklar i publikationen
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Scientific repor ...
- Av lärosätet
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Karolinska Institutet