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Preclinical evaluat...
Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model
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Sanchez, S (författare)
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Bailey, L (författare)
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Ducore, R (författare)
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- Andersson, T (författare)
- Karolinska Institutet
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Nogueira, R (författare)
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Cognard, C (författare)
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Ribo, M (författare)
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Villanova, H (författare)
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Rios, A (författare)
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Galve, I (författare)
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visa färre...
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(creator_code:org_t)
- 2020-01-20
- 2020
- Engelska.
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Ingår i: Journal of neurointerventional surgery. - : BMJ. - 1759-8486 .- 1759-8478. ; 12:10, s. 1008-1013
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The Advanced Thrombectomy System (ANCD) provides a new funnel component designed to reduce clot fragmentation and facilitate retrieval in patients with stroke by locally restricting flow, allowing distal aspiration in combination with a stent retriever (SR).ObjectiveTo evaluate the preclinical efficacy and safety of the ANCD in a swine clot model.MethodsSoft and firm clots were implanted in the lingual and cervical arteries of 11 swine to obtain Thrombolysis in Cerebral Infarction (TICI) 0 blood flow. Mechanical thrombectomy was performed with either a balloon guide catheter+Solitaire 2 stent retriever (BGC+SR, n=13) or ANCD+SR (n=13). TICI flow was evaluated and successful revascularization was defined as TICI 3 (normal perfusion). To characterize safety, a total of 3 passes were performed in each vessel independent of recanalization. Tissues were explanted for histopathological analysis after 3 and 30 days, respectively.ResultsFirst pass reperfusion rates were ANCD+SR: 69% and BGC+SR: 46%. Reperfusion increased after the third pass in both groups (ANCD+SR: 100%, vs BGC+SR: 77%). Recanalization was achieved after an average of 1.4 and 1.9 passes in ANCD+SR and BGC+SR (p=0.095), respectively. Vessel injury was comparable in both groups; endothelial loss at 3 days was the most common injury seen (ANCD+SR: 1.78±1.22; BGC+SR: 2.03±1.20; p=0.73), while other histopathological markers were absent or minimal. Tissues downstream from targeted vessels also showed absence or minimal lesions across both groups.ConclusionsResults in a swine clot model support the high efficacy of the ANCD+SR without causing clinically significant vessel injury potentially related to the new funnel component.
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sanchez, S
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Bailey, L
-
Ducore, R
-
Andersson, T
-
Nogueira, R
-
Cognard, C
-
visa fler...
-
Ribo, M
-
Villanova, H
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Rios, A
-
Galve, I
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visa färre...
- Artiklar i publikationen
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Journal of neuro ...
- Av lärosätet
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Karolinska Institutet