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Skin T cells mainta...
Skin T cells maintain their diversity and functionality in the elderly
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- Koguchi-Yoshioka, H (författare)
- Karolinska Institutet
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- Hoffer, E (författare)
- Karolinska Institutet
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Cheuk, S (författare)
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Matsumura, Y (författare)
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Vo, S (författare)
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Kjellman, P (författare)
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Grema, L (författare)
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Ishitsuka, Y (författare)
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Nakamura, Y (författare)
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Okiyama, N (författare)
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Fujisawa, Y (författare)
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Fujimoto, M (författare)
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- Eidsmo, L (författare)
- Karolinska Institutet
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Clark, RA (författare)
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Watanabe, R (författare)
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(creator_code:org_t)
- 2021-01-04
- 2021
- Engelska.
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 13-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Koguchi-Yoshioka ...
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Hoffer, E
-
Cheuk, S
-
Matsumura, Y
-
Vo, S
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Kjellman, P
-
visa fler...
-
Grema, L
-
Ishitsuka, Y
-
Nakamura, Y
-
Okiyama, N
-
Fujisawa, Y
-
Fujimoto, M
-
Eidsmo, L
-
Clark, RA
-
Watanabe, R
-
visa färre...
- Artiklar i publikationen
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Communications b ...
- Av lärosätet
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Karolinska Institutet