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Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis
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- Bona, K (författare)
- Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Div Populat Sci, Boston, MA 02115 USA.
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- Brazauskas, R (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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- He, NY (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA.
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- Frangoul, HA (författare)
- Seo, S (författare)
- Sharma, A (författare)
- Srivastava, A (författare)
- Steinberg, A (författare)
- Szwajcer, D (författare)
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- Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Div Populat Sci, Boston, MA 02115 USA Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res CIBMTR, Inst Hlth & Equ, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)
- American Society of Hematology, 2021
- 2021
- Engelska.
- Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 137:4, s. 556-568
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
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- Social determinants of health, including poverty, contribute significantly to health outcomes in the United States; however, their impact on pediatric hematopoietic cell transplantation (HCT) outcomes is poorly understood. We aimed to identify the association between neighborhood poverty and HCT outcomes for pediatric allogeneic HCT recipients in the Center for International Blood and Marrow Transplant Research database. We assembled 2 pediatric cohorts undergoing first allogeneic HCT from 2006 to 2015 at age ≤18 years, including 2053 children with malignant disease and 1696 children with nonmalignant disease. Neighborhood poverty exposure was defined a priori per the US Census definition as living in a high-poverty ZIP code (≥20% of persons below 100% federal poverty level) and used as the primary predictor in all analyses. Our primary outcome was overall survival (OS), defined as the time from HCT until death resulting from any cause. Secondary outcomes included relapse and transplantation-related mortality (TRM) in malignant disease, acute and chronic graft-versus-host disease, and infection in the first 100 days post-HCT. Among children undergoing transplantation for nonmalignant disease, neighborhood poverty was not associated with any HCT outcome. Among children undergoing transplantation for malignant disease, neighborhood poverty conferred an increased risk of TRM but was not associated with inferior OS or any other transplantation outcome. Among children with malignant disease, a key secondary finding was that children with Medicaid insurance experienced inferior OS and increased TRM compared with those with private insurance. These data suggest opportunities for future investigation of the effects of household-level poverty exposure on HCT outcomes in pediatric malignant disease to inform care delivery interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- Bona, K
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- He, NY
- Lehmann, L
- Abdel-Azim, H
- Ahmed, IA
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- Al-Homsi, AS
- Aljurf, M
- Arnold, SD
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- Diaz, MA
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- Savani, BN
- Schears, R
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- Sharma, A
- Srivastava, A
- Steinberg, A
- Szwajcer, D
- Wirk, B
- Yoshimi, A
- Khera, N
- Wood, WA
- Hashmi, S
- Duncan, CN
- Saber, W
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