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Genome-wide bioinfo...
Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
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Ferrarini, MG (författare)
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Lal, A (författare)
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Rebollo, R (författare)
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Gruber, AJ (författare)
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Guarracino, A (författare)
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- Gonzalez, IM (författare)
- Karolinska Institutet
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Floyd, T (författare)
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de Oliveira, DS (författare)
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Shanklin, J (författare)
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Beausoleil, E (författare)
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Pusa, T (författare)
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Pickett, BE (författare)
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Aguiar-Pulido, V (författare)
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(creator_code:org_t)
- 2021-05-17
- 2021
- Engelska.
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 590-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China. Here we analyzed public host and viral RNA sequencing data to better understand how SARS-CoV-2 interacts with human respiratory cells. We identified genes, isoforms and transposable element families that are specifically altered in SARS-CoV-2-infected respiratory cells. Well-known immunoregulatory genes including CSF2, IL32, IL-6 and SERPINA3 were differentially expressed, while immunoregulatory transposable element families were upregulated. We predicted conserved interactions between the SARS-CoV-2 genome and human RNA-binding proteins such as the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and eukaryotic initiation factor 4 (eIF4b). We also identified a viral sequence variant with a statistically significant skew associated with age of infection, that may contribute to intracellular host–pathogen interactions. These findings can help identify host mechanisms that can be targeted by prophylactics and/or therapeutics to reduce the severity of COVID-19.
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Till lärosätets databas
- Av författaren/redakt...
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Ferrarini, MG
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Lal, A
-
Rebollo, R
-
Gruber, AJ
-
Guarracino, A
-
Gonzalez, IM
-
visa fler...
-
Floyd, T
-
de Oliveira, DS
-
Shanklin, J
-
Beausoleil, E
-
Pusa, T
-
Pickett, BE
-
Aguiar-Pulido, V
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visa färre...
- Artiklar i publikationen
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Communications b ...
- Av lärosätet
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Karolinska Institutet