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A System Pharmacolo...
A System Pharmacology Multi-Omics Approach toward Uncontrolled Pediatric Asthma
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Abdel-Aziz, MI (författare)
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Neerincx, AH (författare)
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Vijverberg, SJH (författare)
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Hashimoto, S (författare)
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Brinkman, P (författare)
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Gorenjak, M (författare)
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Toncheva, AA (författare)
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Harner, S (författare)
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Brandstetter, S (författare)
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Wolff, C (författare)
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Perez-Garcia, J (författare)
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- Hedman, AM (författare)
- Karolinska Institutet
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- Almqvist, C (författare)
- Karolinska Institutet
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Corcuera-Elosegui, P (författare)
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Korta-Murua, J (författare)
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Sardon-Prado, O (författare)
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Pino-Yanes, M (författare)
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Potocnik, U (författare)
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Kabesch, M (författare)
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Kraneveld, AD (författare)
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van der Zee, AMH (författare)
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(creator_code:org_t)
- 2021-05-28
- 2021
- Engelska.
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Ingår i: Journal of personalized medicine. - : MDPI AG. - 2075-4426. ; 11:6
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- There is a clinical need to identify children with poor asthma control as early as possible, to optimize treatment and/or to find therapeutic alternatives. Here, we present the “Systems Pharmacology Approach to Uncontrolled Pediatric Asthma” (SysPharmPediA) study, which aims to establish a pediatric cohort of moderate-to-severe uncontrolled and controlled patients with asthma, to investigate pathophysiological mechanisms underlying uncontrolled moderate-to-severe asthma in children on maintenance treatment, using a multi-omics systems medicine approach. In this multicenter observational case–control study, moderate-to-severe asthmatic children (age; 6–17 years) were included from four European countries (Netherlands, Germany, Spain, and Slovenia). Subjects were classified based on asthma control and number of exacerbations. Demographics, current and past patient/family history, and clinical characteristics were collected. In addition, systems-wide omics layers, including epi(genomics), transcriptomics, microbiome, proteomics, and metabolomics were evaluated from multiple samples. In all, 145 children were included in this cohort, 91 with uncontrolled (median age = 12 years, 43% females) and 54 with controlled asthma (median age = 11.7 years, 37% females). The two groups did not show statistically significant differences in age, sex, and body mass index z-score distribution. Comprehensive information and diverse noninvasive biosampling procedures for various omics analyses will provide the opportunity to delineate underlying pathophysiological mechanisms of moderate-to-severe uncontrolled pediatric asthma. This eventually might reveal novel biomarkers, which could potentially be used for noninvasive personalized diagnostics and/or treatment.
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Till lärosätets databas
- Av författaren/redakt...
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Abdel-Aziz, MI
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Neerincx, AH
-
Vijverberg, SJH
-
Hashimoto, S
-
Brinkman, P
-
Gorenjak, M
-
visa fler...
-
Toncheva, AA
-
Harner, S
-
Brandstetter, S
-
Wolff, C
-
Perez-Garcia, J
-
Hedman, AM
-
Almqvist, C
-
Corcuera-Elosegu ...
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Korta-Murua, J
-
Sardon-Prado, O
-
Pino-Yanes, M
-
Potocnik, U
-
Kabesch, M
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Kraneveld, AD
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van der Zee, AMH
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visa färre...
- Artiklar i publikationen
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Journal of perso ...
- Av lärosätet
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Karolinska Institutet