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Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis-The IMPROVE Study
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Coggi, D (författare)
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Frigerio, B (författare)
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Bonomi, A (författare)
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Ruscica, M (författare)
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Ferri, N (författare)
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Sansaro, D (författare)
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Ravani, A (författare)
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Ferrante, P (författare)
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Damigella, M (författare)
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Veglia, F (författare)
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Capra, N (författare)
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Lupo, MG (författare)
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Macchi, C (författare)
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Savonen, K (författare)
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- Silveira, A (författare)
- Karolinska Institutet
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Kurl, S (författare)
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Giral, P (författare)
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Pirro, M (författare)
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- Strawbridge, RJ (författare)
- Karolinska Institutet
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- Gigante, B (författare)
- Karolinska Institutet
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Smit, AJ (författare)
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Tremoli, E (författare)
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Amato, M (författare)
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Baldassarre, D (författare)
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(creator_code:org_t)
- 2021-07-19
- 2021
- Engelska.
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Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 9:7
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- (1) Background and purpose: circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators of cholesterol metabolism. Despite this, its role as a player in atherosclerosis development is still matter of debate. Here, we investigated the relationships between this protein and several markers of subclinical atherosclerosis. (2) Methods: the IMPROVE study enrolled 3703 European subjects (54–79 years; 48% men; with ≥3 vascular risk factors), asymptomatic for cardiovascular diseases. PCSK9 levels were measured by ELISA. B-mode ultrasound was used to measure markers of carotid subclinical atherosclerosis. (3) Results: in the crude analysis, PCSK9 levels were associated with several baseline measures of carotid intima-media thickness (cIMT) (all p < 0.0001); with cIMT change over time (Fastest-IMTmax-progr) (p = 0.01); with inter-adventitia common carotid artery diameter (ICCAD) (p < 0.0001); and with the echolucency (Grey Scale Median; GSM) of both carotid plaque and plaque-free common carotid IMT (both p < 0.0001). However, after adjustment for age, sex, latitude, and pharmacological treatment, all the afore-mentioned correlations were no longer statistically significant. The lack of correlation was also observed after stratification for sex, latitude, and pharmacological treatments. (4) Conclusions: in subjects who are asymptomatic for cardiovascular diseases, PCSK9 plasma levels do not correlate with vascular damage and/or subclinical atherosclerosis of extracranial carotid arteries.
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- Av författaren/redakt...
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Coggi, D
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Frigerio, B
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Bonomi, A
-
Ruscica, M
-
Ferri, N
-
Sansaro, D
-
visa fler...
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Ravani, A
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Ferrante, P
-
Damigella, M
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Veglia, F
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Capra, N
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Lupo, MG
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Macchi, C
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Savonen, K
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Silveira, A
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Kurl, S
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Giral, P
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Pirro, M
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Strawbridge, RJ
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Gigante, B
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Smit, AJ
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Tremoli, E
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Amato, M
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Baldassarre, D
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visa färre...
- Artiklar i publikationen
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Biomedicines
- Av lärosätet
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Karolinska Institutet