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Continuity of Genet...
Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course
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van der Laan, CM (författare)
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Morosoli-Garcia, JJ (författare)
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van de Weijer, SGA (författare)
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Colodro-Conde, L (författare)
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Lupton, MK (författare)
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Mitchell, BL (författare)
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McAloney, K (författare)
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Parker, R (författare)
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Burns, JM (författare)
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Hickie, IB (författare)
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Pool, R (författare)
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Hottenga, JJ (författare)
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Martin, NG (författare)
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Medland, SE (författare)
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Nivard, MG (författare)
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Boomsma, DI (författare)
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- 2021-08-14
- 2021
- Engelska.
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Ingår i: Behavior genetics. - : Springer Science and Business Media LLC. - 1573-3297 .- 0001-8244. ; 51:5, s. 592-606
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https://link.springe...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
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van der Laan, CM
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Morosoli-Garcia, ...
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van de Weijer, S ...
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Colodro-Conde, L
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Lupton, MK
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Mitchell, BL
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visa fler...
-
McAloney, K
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Parker, R
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Burns, JM
-
Hickie, IB
-
Pool, R
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Hottenga, JJ
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Martin, NG
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Medland, SE
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Nivard, MG
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Boomsma, DI
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visa färre...
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Behavior genetic ...
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Karolinska Institutet