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Anticancer Potentia...
Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
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Asik, RM (författare)
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Manikkaraja, C (författare)
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Surya, KT (författare)
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Suganthy, N (författare)
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Aarthy, AP (författare)
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Mathe, D (författare)
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Sivakumar, M (författare)
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Archunan, G (författare)
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Padmanabhan, P (författare)
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Gulyas, B (författare)
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- 2021-11-22
- 2021
- Engelska.
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Ingår i: Nanomaterials (Basel, Switzerland). - : MDPI AG. - 2079-4991. ; 11:11
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- This study reports the synthesis of silver nanoparticles using amino acid L-histidine as a reducing and capping agent as an eco-friendly approach. Fabricated L-histidine-capped silver nanoparticles (L-HAgNPs) were characterized by spectroscopic and microscopic studies. Spherical shaped L-HAgNPs were synthesized with a particle size of 47.43 ± 19.83 nm and zeta potential of −20.5 ± 0.95 mV. Results of the anticancer potential of L-HAgNPs showed antiproliferative effect against SiHa cells in a dose-dependent manner with an IC50 value of 18.25 ± 0.36 µg/mL. Fluorescent microscopic analysis revealed L-HAgNPs induced reactive oxygen species (ROS) mediated mitochondrial dysfunction, leading to activation of apoptotic pathway and DNA damage eventually causing cell death. To conclude, L-HAgNPs can act as promising candidates for cervical cancer therapy.
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- Av författaren/redakt...
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Asik, RM
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Manikkaraja, C
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Surya, KT
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Suganthy, N
-
Aarthy, AP
-
Mathe, D
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visa fler...
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Sivakumar, M
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Archunan, G
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Padmanabhan, P
-
Gulyas, B
-
visa färre...
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Nanomaterials (B ...
- Av lärosätet
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Karolinska Institutet