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The Spectrum of B C...
The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease
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Smeets, D (författare)
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- Gistera, A (författare)
- Karolinska Institutet
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- Malin, SG (författare)
- Karolinska Institutet
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Tsiantoulas, D (författare)
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(creator_code:org_t)
- 2022-04-15
- 2022
- Engelska.
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Ingår i: Frontiers in cardiovascular medicine. - : Frontiers Media SA. - 2297-055X. ; 9, s. 864602-
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- B cells are a core element of the pathophysiology of atherosclerotic cardiovascular disease (ASCVD). Multiple experimental and epidemiological studies have revealed both protective and deleterious functions of B cells in atherosclerotic plaque formation. The spearhead property of B cells that influences the development of atherosclerosis is their unique ability to produce and secrete high amounts of antigen-specific antibodies that can act at distant sites. Exposure to an atherogenic milieu impacts B cell homeostasis, cell differentiation and antibody production. However, it is not clear whether B cell responses in atherosclerosis are instructed by atherosclerosis-specific antigens (ASA). Dissecting the full spectrum of the B cell properties in atherosclerosis will pave the way for designing innovative therapies against the devastating consequences of ASCVD.
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- art (ämneskategori)
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