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IMPAIRED PROMIS PHYSICAL FUNCTION IN IDIOPATHIC INFLAMMATORY MYOPATHY PATIENTS: RESULTS FROM THE MULTICENTER COVAD PATIENT REPORTED E-SURVEY

Yoshida, A (författare)
Nippon Medical School Graduate School of Medicine, Department of Allergy and Rheumatology, Tokyo, Japan
Kim, M (författare)
University of Illinois College of Medicine Peoria, Center for Outcomes Research, Department of Internal Medicine, Illinois, United States of America
Kuwana, M (författare)
Nippon Medical School Graduate School of Medicine, Department of Allergy and Rheumatology, Tokyo, Japan
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R, N (författare)
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Clinical Immunology and Rheumatology, Lucknow, India
Lilleker, JB (författare)
The University of Manchester, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Manchester, United Kingdom; Northern Care Alliance NHS Foundation Trust, Manchester Centre for Clinical Neurosciences, Salford, United Kingdom
Sen, P (författare)
Maulana Azad Medical College (MAMC), New Delhi, India
Agarwal, V (författare)
Mahatma Gandhi Mission Medical College, Navi Mumbai, India
Kardes, S (författare)
Istanbul University, Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul, Turkey
Day, J (författare)
Royal Melbourne Hospital, Department of Rheumatology, Parkville, Australia; University of Melbourne, Department of Medical Biology, Parkville, Australia; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Makol, A (författare)
Mayo Clinic, Division of Rheumatology, Rochester, Minnesota, United States of America,Centro Médico Nacional La Raza, Departamento de Reumatología Hospital de Especialidades Dr. Antonio Fraga Mouret, Mexico City, Mexico
Milchert, M (författare)
Pomeranian Medical University in Szczecin, Department of Rheumatology, Internal Medicine, Geriatrics and Clinical Immunology, Szczecin, Poland
Gheita, TA (författare)
Cairo University, Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo, Egypt
Salim, B (författare)
Fauji Foundation Hospital, Rheumatology Department, Rawalpindi, Pakistan
Velikova, T (författare)
University Hospital “Lozenetz”, Department of Clinical Immunology, Medical Faculty, Sofia, Bulgaria
Gracia-Ramos, AE (författare)
National Medical Center “La Raza”, Department of Internal Medicine, General Hospital, Mexico City, Mexico,University of Pittsburgh School of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, Pennsylvania, United States of America
Parodis, Ioannis, 1981- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden; Örebro University, Department of Rheumatology, Faculty of Medicine and Health, Örebro, Sweden
Selva-O'callaghan, A (författare)
Vall D’hebron General Hospital, Universitat Autonoma de Barcelona, Systemic Autoimmune Diseases Unit, Internal Medicine Department, Barcelona, Spain
Nikiphorou, E (författare)
King’s College London, Centre for Rheumatic Diseases, London, United Kingdom; King’s College Hospital, Rheumatology Department, London, United Kingdom
Chatterjee, T (författare)
University of Illinois College of Medicine at Peoria, Department of Internal Medicine, Illinois, United States of America
Tan, AL (författare)
Leeds Teaching Hospitals Trust, NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom; University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom
Nune, A (författare)
Southport and Ormskirk Hospital NHS Trust, Department of Rheumatology, Southport, United Kingdom
Cavagna, L (författare)
Università degli studi di Pavia, Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Pavia, Lombardy, Italy
Saavedra, MA (författare)
Shinjo, SK (författare)
Universidade de Sao Paulo, Division of Rheumatology, Faculdade de Medicina FMUSP, Sao Paulo, Brazil
Ziade, N (författare)
Saint-Joseph University, Rheumatology Department, Beirut, Lebanon; Hotel-Dieu de France Hospital, Rheumatology Department, Beirut, Lebanon
Knitza, J (författare)
Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen- Nürnberg, Medizinische Klinik 3 - Rheumatologie und Immunologie, Erlangen, Germany
Distler, O (författare)
University Hospital Zurich, University of Zurich, Department of Rheumatology, Zurich, Switzerland
Chinoy, H (författare)
The University of Manchester, Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Manchester, United Kingdom; Manchester University NHS Foundation Trust, The University of Manchester, National Institute for Health Research Manchester Biomedical Research Centre, Manchester, United Kingdom; Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Department of Rheumatology, Salford, United Kingdom
Agarwal, V (författare)
Aggarwal, R (författare)
Gupta, L (författare)
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Clinical Immunology and Rheumatology, Lucknow, India; Royal Wolverhampton Hospitals NHS Trust, Department of Rheumatology, Wolverhampton, United Kingdom
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 (creator_code:org_t)
2022-05-23
2022
Engelska.
Ingår i: ANNALS OF THE RHEUMATIC DISEASES. - : BMJ. - 0003-4967 .- 1468-2060. ; 81, s. 720-722
Relaterad länk:
https://doi.org/10.1...
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http://kipublication...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Evaluation of physical function is fundamental in the management of idiopathic inflammatory myopathies (IIMs). Patient-Reported Outcome Measurement Information System (PROMIS) is a National Institute of Health initiative established in 2004 to develop patient-reported outcome measures (PROMs) with improved validity and efficacy. PROMIS Physical Function (PF) short forms have been validated for use in IIMs [1].ObjectivesTo investigate the physical function status of IIM patients compared to those with non-IIM autoimmune diseases (AIDs) and healthy controls (HCs) utilizing PROMIS PF data obtained in the coronavirus disease-2019 (COVID-19) Vaccination in Autoimmune Diseases (COVAD) study, a large-scale, international self-reported e-survey assessing the safety of COVID-19 vaccines in AID patients [2].MethodsThe survey data regarding demographics, IIM and AID diagnosis, disease activity, and PROMIS PF short form-10a scores were extracted from the COVAD study database. The disease activity (active vs inactive) of each patient was assessed in 3 different ways: (1) physician’s assessment (active if there was an increased immunosuppression), (2) patient’s assessment (active vs inactive as per patient), and (3) current steroid use. These 3 definitions of disease activity were applied independently to each patient. PROMIS PF-10a scores were compared between each disease category (IIMs vs non-IIM AIDs vs HCs), stratified by disease activity based on the 3 definitions stated above, employing negative binominal regression model. Multivariable regression analysis adjusted for age, gender, and ethnicity was performed clustering countries, and the predicted PROMIS PF-10a score was calculated based on the regression result. Factors affecting PROMIS PF-10a scores other than disease activity were identified by another multivariable regression analysis in the patients with inactive disease (IIMs or non-IIM AIDs).Results1057 IIM patients, 3635 non-IIM AID patients, and 3981 HCs responded to the COVAD survey until August 2021. The median age of the respondents was 43 [IQR 30-56] years old, and 74.8% were female. Among IIM patients, dermatomyositis was the most prevalent diagnosis (34.8%), followed by inclusion body myositis (IBM) (23.6%), polymyositis (PM) (16.2%), anti-synthetase syndrome (11.8%), overlap myositis (7.9%), and immune-mediated necrotizing myopathy (IMNM) (4.6%). The predicted mean of PROMIS PF-10a scores was significantly lower in IIMs compared to non-IIM AIDs or HCs (36.3 [95% (CI) 35.5-37.1] vs 41.3 [95% CI 40.2-42.5] vs 46.2 [95% CI 45.8-46.6], P < 0.001), irrespective of disease activity or the definitions of disease activity used (physician’s assessment, patient’s assessment, or steroid use) (Figure 1). The largest difference between active IIMs and non-IIM AIDs was observed when the disease activity was defined by patient’s assessment (35.0 [95% CI 34.1-35.9] vs 40.1 [95% CI 38.7-41.5]). Considering the subgroups of IIMs, the scores were significantly lower in IBM in comparison with non-IBM IIMs (P < 0.001). The independent factors associated with low PROMIS PF-10a scores in the patients with inactive disease were older age, female gender, and the disease category being IBM, PM, or IMNM.ConclusionPhysical function is significantly impaired in IIMs compared to non-IIM AIDs or HCs, even in patients with inactive disease. The elderly, women, and IBM groups are the worst affected, suggesting that developing targeted strategies to minimize functional disability in certain groups may improve patient reported physical function and disease outcomes.References[1]Saygin D, Oddis CV, Dzanko S, et al. Utility of patient-reported outcomes measurement information system (PROMIS) physical function form in inflammatory myopathy. Semin Arthritis Rheum. 2021; 51: 539-46.[2]Sen P, Gupta L, Lilleker JB, et al. COVID-19 vaccination in autoimmune disease (COVAD) survey protocol. Rheumatol Int. 2022; 42: 23-9.AcknowledgementsThe authors thank all respondents for filling the questionnaire. The authors thank The Myositis Association, Myositis India, Myositis UK, the Myositis Global Network, Cure JM, Cure IBM, Sjögren’s India Foundation, EULAR PARE, and various other patient support groups and organizations for their invaluable contribution in the dissemination of this survey among patients which made the data collection possible. The authors also thank all members of the COVAD study group.Disclosure of InterestsNone declared

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

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