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Body Mass Index Mea...
Body Mass Index Measured Repeatedly over 42 Years as a Risk Factor for Ischemic Stroke: The HUNT Study
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Horn, JW (författare)
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Feng, TT (författare)
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Morkedal, B (författare)
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Aune, D (författare)
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Strand, LB (författare)
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Horn, J (författare)
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Mukamal, KJ (författare)
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- Janszky, I (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2023-02-28
- 2023
- Engelska.
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 15:5
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Background: Higher BMI in middle age is associated with ischemic stroke, but little is known about BMI over adulthood, and the risk for ischemic stroke as most studies relied on a single measurement of BMI. Methods: BMI was measured four times over a period of 42 years. We calculated average BMI values and group-based trajectory models and related these to the prospective risk of ischemic stroke after the last examination in Cox models with a follow-up time of 12 years. Results: A total of 14,139 participants, with a mean age of 65.2 years and 55.4% women, had information on BMI from all four examinations, and we observed 856 ischemic strokes. People with overweight and obesity over adulthood had a higher risk for ischemic stroke with a multivariable-adjusted hazard ratio of 1.29 (95% CI 1.11−1.48) and 1.27 (95% CI 0.96−1.67), respectively, when compared to normal weight participants. Excess weight tended to have stronger effects earlier than later in life. A trajectory of developing obesity throughout life was associated with higher risk than other trajectories. Conclusions: High average BMI, especially at an early age, is a risk factor for ischemic stroke. Early weight control and long-term weight reduction for those with high BMI may decrease the later occurrence of ischemic stroke.
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