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Dual effect of inte...
Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression
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Valentin, A (författare)
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Lu, WH (författare)
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Rosati, M (författare)
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Schneider, R (författare)
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- Albert, J (författare)
- Karolinska Institutet
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- Karlsson, A (författare)
- Karolinska Institutet
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Pavlakis, GN (författare)
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(creator_code:org_t)
- 1998-07-21
- 1998
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 95:15, s. 8886-8891
- Relaterad länk:
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https://www.pnas.org...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- We report that interleukin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms. It differentially regulates the two major HIV-1 coreceptors, CCR5 and CXCR4, in human peripheral blood mononuclear cells, increasing CXCR4 and decreasing CCR5 expression in primary CD4(+) T-lymphocytes. In addition, IL-4 stimulates the expression of all HIV-1 isolates via a transcriptional activation mechanism. The combination of these effects results in increased propagation of CXCR4-using and inhibition of CCR5-using HIV-1 strains. IL-4 also activates HIV-1 expression in primary monocytes/macrophages but does not affect CCR5 expression. These results identify IL-4 as an important regulator of HIV-1 and suggest a critical role for this cytokine in the control of viral evolution and in the phenotypic switch from non-syncytia-inducing to syncytia-inducing, which leads to accelerated disease progression.
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