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2B4/CD48-mediated r...
2B4/CD48-mediated regulation of lymphocyte activation and function
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- Assarsson, E (author)
- Karolinska Institutet
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Kambayashi, T (author)
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- Persson, CM (author)
- Karolinska Institutet
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- Chambers, BJ (author)
- Karolinska Institutet
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- Ljunggren, HG (author)
- Karolinska Institutet
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(creator_code:org_t)
- The American Association of Immunologists, 2005
- 2005
- English.
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In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 175:4, s. 2045-2049
- Related links:
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http://www.jimmunol....
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http://kipublication...
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https://doi.org/10.4...
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Abstract
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- 2B4 (CD244) is a member of the CD2 subset of the Ig superfamily. This molecule is expressed on innate immune cells, including NK cells, and on subsets of T cells. The 2B4 molecule interacts with CD48, which is widely expressed on hemopoietic cells. Although earlier reports demonstrated a role for 2B4 as an activating receptor in both mice and humans, recent studies of 2B4-deficient mice have suggested that 2B4 functions predominantly as an inhibitory receptor in mice. In addition, 2B4 may also act as a costimulatory ligand for cells expressing CD48. Thus, the 2B4 molecule is more multifunctional than previously understood. In this study, we delineate the current view of 2B4-CD48 interactions among lymphocytes and other cells.
Publication and Content Type
- ref (subject category)
- art (subject category)
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