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A function of the h...
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
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- Chen, MT (författare)
- Karolinska Institutet
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Billaud, JN (författare)
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- Sallberg, M (författare)
- Karolinska Institutet
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Guidotti, LG (författare)
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Chisari, FV (författare)
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Jones, J (författare)
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Hughes, J (författare)
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Milich, DR (författare)
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(creator_code:org_t)
- 2004-10-05
- 2004
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 101:41, s. 14913-14918
- Relaterad länk:
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http://www.pnas.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A unique characteristic of the hepatitis B virus is the production of a secreted form (precore or HBeAg) of the structural nucleocapsid (core or HBcAg). By using T cell receptor (TCR) transgenic (Tg) and TCR × HBc/HBeAg double- and triple-Tg pairs, we demonstrate that HBeAg elicits T cell tolerance, whereas HBcAg is nontolerogenic in this system. In fact, TCR × HBc double-Tg mice spontaneously seroconvert to IgG anti-HBc positivity at an early age. However, the presence of HBeAg in the serum of TCR × HBc × HBe triple-Tg mice prevents anti-HBc seroconversion. HBeAg mediates its immunoregulatory effect by eliciting tolerance in HBc/HBeAg-specific T cells. The results suggest that hepadnaviruses have retained a secretory form of the nucleoprotein because it functions as a T cell tolerogen and regulates the immune response to the intracellular nucleocapsid. This HBeAg-mediated immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
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- art (ämneskategori)
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