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Sequence variants o...
Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study
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Zheng, SL (författare)
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- Augustsson-Balter, K (författare)
- Karolinska Institutet
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Chang, BL (författare)
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- Hedelin, M (författare)
- Karolinska Institutet
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Li, LW (författare)
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- Adami, HO (författare)
- Karolinska Institutet
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Bensen, J (författare)
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Li, G (författare)
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Johnasson, JE (författare)
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Turner, AR (författare)
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Adams, TS (författare)
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Meyers, DA (författare)
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Isaacs, WB (författare)
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Xu, JF (författare)
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- Gronberg, H (författare)
- Umeå universitet,Onkologi
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(creator_code:org_t)
- 2004-04-15
- 2004
- Engelska.
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Ingår i: Cancer research. - : American Association for Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 64:8, s. 2918-2922
- Relaterad länk:
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http://cancerres.aac...
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Inflammation has been implicated as an etiological factor in several human cancers. Growing evidence suggests that chronic inflammation may also play a role in the etiology of prostate cancer. Considering that genetic susceptibility is a major risk factor for this disease, we hypothesize that sequence variants in genes that regulate inflammation may modify individual susceptibility to prostate cancer. The lipopolysaccharide receptor Toll-like receptor 4 (TLR4) is a central player in the signaling pathways of the innate immune response to infection by Gram-negative bacteria and is an important candidate inflammatory gene. We performed a systematic genetic analysis of TLR4 sequence variants by evaluating eight single-nucleotide polymorphisms that span the entire gene among 1383 newly diagnosed prostate cancer patients and 780 age- and residence-matched controls in Sweden. We found an association between a sequence variant (11381G/C) in the 3′-untranslated region of the TLR4 gene and prostate cancer risk. The frequency of the variant genotypes (CG or CC) was significantly higher in the patients (24.1%) than in the controls (19.7%; P = 0.02). The frequency of risk genotypes among patients diagnosed before the age of 65 years was even higher (26.3%). Compared with men who had the wild-type genotype of this single-nucleotide polymorphism (GG), those with GC or CC genotypes had a 26% increased risk for prostate cancer (odds ratio, 1.26; 95% confidence interval, 1.01–1.57) and 39% increased risk increased risk for early onset prostate cancer (before age 65 years; odds ratio, 1.39; 95% confidence interval, 1.02–1.91). The risk attributable to this variant for prostate cancer in Sweden was estimated to be 4.9%. Although the biological mechanism of the observed association remains to be elucidated, our finding supports a role for a bacteria-associated response pathway, possibly acting via inflammation, in the development of prostate cancer.
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zheng, SL
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Augustsson-Balte ...
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Chang, BL
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Hedelin, M
-
Li, LW
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Adami, HO
-
visa fler...
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Bensen, J
-
Li, G
-
Johnasson, JE
-
Turner, AR
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Adams, TS
-
Meyers, DA
-
Isaacs, WB
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Xu, JF
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Gronberg, H
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visa färre...
- Artiklar i publikationen
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Cancer research
- Av lärosätet
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Karolinska Institutet
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Umeå universitet