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Characterization of...
Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332
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Nilsson, S (författare)
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- Moll, K (författare)
- Karolinska Institutet
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- Angeletti, D (författare)
- Karolinska Institutet
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Albrecht, L (författare)
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Kursula, I (författare)
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Jiang, N (författare)
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Sun, X (författare)
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Berzins, K (författare)
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- Wahlgren, M (författare)
- Karolinska Institutet
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Chen, Q (författare)
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(creator_code:org_t)
- Hindawi Limited, 2011
- 2011
- Engelska.
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Ingår i: Malaria research and treatment. - : Hindawi Limited. - 2044-4362. ; 2011, s. 671439-
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https://doi.org/10.4...
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Abstract
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- Studies on Pf332, a major Plasmodium falciparum blood-stage antigen, have largely been hampered by the cross-reactive nature of antibodies generated against the molecule due to its high content of repeats, which are present in other malaria antigens. We previously reported the identification of a conserved domain in Pf332 with a high degree of similarity to the Duffy-binding-like (DBL) domains of the erythrocyte-binding-like (EBL) family. We here describe that antibodies towards Pf332-DBL are induced after repeated exposure to P. falciparum and that they are acquired early in life in areas of intense malaria transmission. Furthermore, a homology model of Pf332-DBL was found to be similar to the structure of the EBL-DBLs. Despite their similarities, antibodies towards Pf332-DBL did not display any cross-reactivity with EBL-proteins as demonstrated by immunofluorescence microscopy, Western blotting, and peptide microarray. Thus the DBL domain is an attractive region to use in further studies on the giant Pf332 molecule.
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Nilsson, S
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Moll, K
-
Angeletti, D
-
Albrecht, L
-
Kursula, I
-
Jiang, N
-
visa fler...
-
Sun, X
-
Berzins, K
-
Wahlgren, M
-
Chen, Q
-
visa färre...
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Malaria research ...
- Av lärosätet
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Karolinska Institutet