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Serological assessm...
Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions
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Byström, JW (author)
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Vikström, L (author)
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Rosendal, E (author)
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Gröning, R (author)
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Gwon, YD (author)
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Nilsson, E (author)
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Sharma, A (author)
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Espaillat, A (author)
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- Hanke, L (author)
- Karolinska Institutet
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- McInerney, G (author)
- Karolinska Institutet
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Puhar, A (author)
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Cava, F (author)
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- Karlsson Hedestam, GB (author)
- Karolinska Institutet
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Thunberg, T (author)
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Monsen, T (author)
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Elgh, F (author)
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Evander, M (author)
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Johansson, A (author)
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Överby, AK (author)
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Ahlm, C (author)
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Normark, J (author)
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Forsell, MN (author)
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2022
- 2022
- English.
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
- Related links:
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https://www.medrxiv....
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture is usually performed by trained staff at health care centers. Long travel distances may introduce a bias of testing towards relatively large communities with close access to health care centers. Rural regions may thus be overlooked. Here, we demonstrate a sensitive method to measure antibodies to the S-protein of SARS-CoV-2. We adapted and optimized this assay for clinical use together with capillary blood sampling to meet the geographical challenges of serosurveillance. Finally, we tested remote at-home capillary blood sampling together with centralized assessment of S-specific IgG in a rural region of northern Scandinavia that encompasses 55,185 sq kilometers. We conclude that serological assessment from capillary blood sampling gives comparable results as analysis of venous blood. Importantly, at-home sampling enabled citizens living in remote rural areas access to centralized and sensitive laboratory antibody tests.
Publication and Content Type
- vet (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Byström, JW
-
Vikström, L
-
Rosendal, E
-
Gröning, R
-
Gwon, YD
-
Nilsson, E
-
show more...
-
Sharma, A
-
Espaillat, A
-
Hanke, L
-
McInerney, G
-
Puhar, A
-
Cava, F
-
Karlsson Hedesta ...
-
Thunberg, T
-
Monsen, T
-
Elgh, F
-
Evander, M
-
Johansson, A
-
Överby, AK
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Ahlm, C
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Normark, J
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Forsell, MN
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show less...
- Articles in the publication
- medRxiv : the pr ...
- By the university
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Karolinska Institutet