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Solidification to i...
Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges
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- Joyce, Paul, 1989 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Dening, Tahnee J. (författare)
- University of South Australia
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- Meola, Tahlia R. (författare)
- University of South Australia
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- Schultz, Hayley B. (författare)
- University of South Australia
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- Holm, René (författare)
- Roskilde Universitet (RUC),Roskilde University (RUC)
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- Thomas, Nicky (författare)
- University of South Australia
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- Prestidge, Clive A. (författare)
- University of South Australia
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Advanced Drug Delivery Reviews. - : Elsevier BV. - 0169-409X .- 1872-8294. ; 142, s. 102-117
- Relaterad länk:
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https://unisa.alma.e...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid formulations has not translated into widespread commercial success, due to their susceptibility to long term storage and in vivo precipitation issues. One strategy that has emerged to overcome such limitations, is to combine the solubilisation and dissolution enhancing properties of lipids with the stabilising effects of solid carrier materials. The development of intelligent hybrid drug formulations has presented new opportunities to harness the potential of emulsified lipids in optimising oral bioavailability for lipophilic therapeutics. Specific emphasis of this review is placed on the impact of solidification approaches and excipients on the biopharmaceutical performance of self-emulsifying lipids, with findings highlighting the key design considerations that should be implemented when developing hybrid lipid-based formulations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Annan teknik -- Övrig annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies -- Other Engineering and Technologies not elsewhere specified (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik -- Miljöledning (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering -- Environmental Management (hsv//eng)
Nyckelord
- SEDDS
- Lipid-based drug delivery system
- Poorly water-soluble drugs
- Bioavailability
- Solidification
- Self-emulsifying lipids
- Oral delivery
- Pharmacokinetics
- Lipid-based formulation
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- ref (ämneskategori)
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