Validation of local brain kinematics of a novel rat brain finite element model under rotational acceleration and its application towards the clarification of Diffuse Axonal Injury mechanisms

• Relative brain-skull displacement under head rotational acceleration in rats was evaluated experimentally. For this, a thin pin was entered the cortex and rigidly attached to the skull prior to impact. For peak rotational accelerations of 1.7 Mrad/s2, the pin scarred the brain cortex; 1.2 mm superficially and less centrally. These measurements were used to validate the brain kinematics of a new anatomically detailed FE model of the head-neck complex of a rat. This model is intended to be used to clarify brain loading mechanisms and to develop brain tissue injury threshold for Diffuse Axonal Injuries as detected through immune-histology.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Maskinteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Mechanical Engineering (hsv//eng)

Nyckelord

(safety)

Diffuse Axonal Injuries

finite element method (FEM)

injury mechanism

Publikations- och innehållstyp

kon (ämneskategori)

vet (ämneskategori)