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Putative metabolite...
Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach
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- Vitale, Marilena (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Hanhineva, Kati, 1972 (författare)
- Turun Yliopisto,University of Turku,Itä-Suomen Yliopisto,University of Eastern Finland,Chalmers tekniska högskola,Chalmers University of Technology
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- Koistinen, Ville Mikael (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Auriola, Seppo (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Paananen, Jussi (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Costabile, Giuseppina (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Della Pepa, Giuseppe (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Rivellese, Angela A. (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Riccardi, Gabriele (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Giacco, Rosalba (författare)
- Consiglo Nazionale Delle Richerche
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- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Nutrition, Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 31:4, s. 1156-1165
- Relaterad länk:
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
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- Background and aims: Wholegrain cereals have been implicated in the reduction of lifestyle-related chronic diseases risk including cardiovascular diseases and type 2 diabetes. Molecular mechanisms responsible for the beneficial health effects are not entirely understood. The aims of this study were 1) to identify new potential plasma biomarker candidate metabolites of wholegrain cereal foods intake and 2) to examine whether some putative metabolites associated with wholegrain foods intake may play a role in the improvement of cardiometabolic risk factors. Methods and results: Analysis have been conducted in 54 individuals with metabolic syndrome of both genders, age 40–65 years, randomly assigned to 2 dietary interventions lasting 12-week: 1) wholegrain enriched diet (n = 28), and 2) refined-wheat cereals diet (control diet) (n = 26). Nontargeted metabolite profiling analysis was performed on fasting plasma samples collected at baseline and at the end of the experimental diets. Our data show that, at the end of the intervention, a higher intake of wholegrain (tertile 3) was significantly associated with a marked increase in several lipid compounds, as PC (20:4/16:1), LPC (20:4), LPC (22:6), LPC (18:3), LPC (22:5), and a phenolic compound (P < .05 for all). In the wholegrain group, higher concentrations of these metabolites (tertile 3 vs tertile 1 of each metabolite) were significantly associated with lower postprandial insulin and triglyceride responses (P < .05) by 29% and 37%, respectively. Conclusion: These observations suggest a possible role of lipid and polyphenol metabolites in the postprandial metabolic benefits of wholegrains in subjects at high risk of cardiovascular disease. In addition, they provide insight into the role of these metabolites as potential candidate biomarkers of wholegrain foods. The study was registered on ClinicalTrials.gov (identifier: NCT00945854).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Wholegrain cereals
- Metabolic effect
- Dietary biomarker
- Metabolomics
- Nontargeted metabolite profiling
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Till lärosätets databas
- Av författaren/redakt...
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Vitale, Marilena
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Hanhineva, Kati, ...
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Koistinen, Ville ...
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Auriola, Seppo
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Paananen, Jussi
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Costabile, Giuse ...
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visa fler...
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Della Pepa, Gius ...
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Rivellese, Angel ...
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Riccardi, Gabrie ...
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Giacco, Rosalba
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Annan klinisk me ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Nutrition, Metab ...
- Av lärosätet
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Chalmers tekniska högskola