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Quantification of T...
Quantification of True Lumen Helical Morphology and Chirality in Type B Aortic Dissections
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- Bondesson, Johan, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Suh, Ga-Young (författare)
- The California State University, United States,Stanford University
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- Lundh, Torbjörn, 1965 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Dake, Michael D. (författare)
- University of Arizona
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- Lee, Jason T. (författare)
- Stanford University
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- Cheng, Christopher P. (författare)
- Stanford University
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visa färre...
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(creator_code:org_t)
- American Physiological Society, 2021
- 2021
- Engelska.
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Ingår i: American Journal of Physiology - Heart and Circulatory Physiology. - : American Physiological Society. - 1522-1539 .- 0363-6135. ; 320:2, s. H901-H911
- Relaterad länk:
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https://research.cha...
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https://doi.org/10.1...
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https://research.cha...
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https://doi.org/10.1...
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visa färre...
Abstract
Ämnesord
Stäng
- Chirality is a fundamental property in many biologic systems. Motivated by previous observations of helical aortic blood flow, aortic tissue fibers, and propagation of aortic dissections, we introduce methods to characterize helical morphology of aortic dissections. After validation on computer generated phantoms, the methods were applied to patients with type B dissection. For this cohort, there was a distinct bimodal distribution of helical propagation of the dissection with either achiral or exclusively right-handed chirality, with no intermediate cases or left-handed cases. This clear grouping indicates that dissection propagation favors these two modes, potentially due to the right-handedness of helical aortic blood flow and cell orientation. The characterization of dissection chirality and quantification of helical morphology advances our understanding of dissection pathology and lays a foundation for applications in clinical research and treatment practice. For example, the chirality and magnitude of helical metrics of dissections may indicate risk of dissection progression, help define treatment and surveillance strategies, and enable development of novel devices that account for various helical morphologies.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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