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The effect of cipro...
The effect of ciprofloxacin injection on genetically absence prone (Wag/Rij) Rat's electroencephalogram characteristics
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- Moghimi, A. (författare)
- Ferdowsi University of Mashhad
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- Mollazadeh, S. (författare)
- Mashhad University of Medical Sciences
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- Rassouli, F. B. (författare)
- Ferdowsi University of Mashhad
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visa fler...
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- Shiee, Reza, 1978 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Khalilzade, M. A. (författare)
- Islamic Azad University
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visa färre...
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: Basic and Clinical Neuroscience. - 2008-126X. ; 4:1, s. 31-35
- Relaterad länk:
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https://research.cha...
Abstract
Ämnesord
Stäng
- Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- article
- risk assessment
- nonhuman
- Absence epilepsy
- animal model
- 4 aminobutyric acid metabolism
- animal experiment
- Wag/rij
- rat
- electroencephalography
- male
- electrode implant
- magnesium
- seizure susceptibility
- controlled study
- brain cortex
- experimental rat
- ECG abnormality
- animal tissue
- absence
- Ciprofloxacin
- neuropathology
- pathophysiology
- EEG
- causal attribution
- GABAergic system
- neurotoxicity
- spike wave
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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