An efficient 3D deep convolutional network for Alzheimer's disease diagnosis using MR images

• Automatic extraction of features from MRI brain scans and diagnosis of Alzheimer’s Disease (AD) remain a challenging task. In this paper, we propose an efficient and simple three dimensional convolutional network (3D ConvNet) architecture that is able to achieve high performance for detection of AD on a relatively large dataset. The proposed 3D ConvNet consists of five convolutional layers for feature extraction, followed by three fully-connected layers for AD/NC classification. The main contributions of the paper include: (a) propose a novel and effective 3D ConvNet architecture; (b) study the impact of hyper-parameter selection on the performance of AD classification; (c) study the impact of pre-processing; (d) study the impact of data partitioning; (e) study the impact of dataset size. Experiments conducted on an ADNI dataset containing 340 subjects and 1198 MRI brain scans have resulted good performance (with the test accuracy of 98.74%, 100% AD detection rate and 2,4% false alarm). Comparisons with 7 existing state-of-the-art methods have provided strong support to the robustness of the proposed method.

Subject headings

NATURVETENSKAP  -- Data- och informationsvetenskap -- Datorseende och robotik (hsv//swe)

NATURAL SCIENCES  -- Computer and Information Sciences -- Computer Vision and Robotics (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Image Processing (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

MR imaging.

computer-aided diagnosis

automatic feature learning

deep learning

3D deep convolutional networks

Alzheimer’s disease detection

Alzheimer's disease detection

3D deep convolutional networks

automatic feature learning

deep learning

computer-aided diagnosis

MR imaging

Publication and Content Type

kon (subject category)

ref (subject category)