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Coupling cell divis...
Coupling cell division to metabolic pathways through transcription
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- Holland, Petter, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mondeel, Thierry D.G.A. (författare)
- Universiteit Van Amsterdam,University of Amsterdam
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visa fler...
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- Barberis, Matteo (författare)
- Universiteit Van Amsterdam,University of Amsterdam
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visa färre...
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics. ; , s. 74-93
- Relaterad länk:
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Gene expression
- Budding yeast
- Forkhead (Fkh) transcription factors
- Transcriptional regulation
- Metabolism
- Cell cycle
- Data analysis
- ChIP-exo
- ChIP-seq
- Chromatin immunoprecipitation (ChIP)
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