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ToF-SIMS as a tool ...
ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems
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Kotze, Helen L. (författare)
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Armitage, Emily G. (författare)
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Fletcher, John, 1978 (författare)
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visa fler...
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Henderson, Alex (författare)
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Williams, Kaye J. (författare)
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Lockyer, Nicholas P. (författare)
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Vickerman, John C. (författare)
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visa färre...
- 2013
- 2013
- Engelska.
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Ingår i: Surface and Interface Analysis. - 1096-9918 .- 0142-2421. ; 45:1, s. 277-281
- Relaterad länk:
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https://research.cha...
Abstract
Ämnesord
Stäng
- Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is emerging as a tool for studying the metabolism of disease. ToF-SIMS enables chemical specificity in addition to high spatial resolution imaging of biological samples from cells to tissue. Here, ToF-SIMS has been used to investigate the metabolic regulation of hypoxia-induced chemoresistance to doxorubicin treatment using multicellular tumour spheroids. Imaging principal component analysis (PCA) was used as a tool to identify the regions of chemistry present within the image that differ as a result of drug treatment. A series of metabolite ToF-SIMS spectra were acquired, which were used to identify quasi-molecular ions and fragments correlated to the PCA loading plots. Metabolite patterns have been identified as potential biomarkers of hypoxia-induced chemoresistance.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Publikations- och innehållstyp
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- ref (ämneskategori)
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