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Repeatability and r...
Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems
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- Waterton, John C. (author)
- University of Manchester,Bioxydyn Ltd
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- Hines, Catherine D.G. (author)
- Merck Sharp And Dohme Corp., US
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- Hockings, Paul, 1956 (author)
- Chalmers University of Technology,Antaros Medical AB
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- Laitinen, Iina (author)
- Sanofi-Aventis Deutschland GmbH
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- Ziemian, Sabina (author)
- Bayer AG,Bayer Pharma AG
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- Campbell, Simon (author)
- GlaxoSmithKline,SmithKline Beecham Pharmaceuticals
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- Gottschalk, Michael (author)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Faculty of Medicine,Lund University Research Groups
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- Green, Claudia (author)
- Bayer AG,Bayer Pharma AG
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- Haase, Michael (author)
- GlaxoSmithKline,SmithKline Beecham Pharmaceuticals
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- Hassemer, Katja (author)
- Sanofi-Aventis Deutschland GmbH
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- Juretschke, Hans Paul (author)
- Sanofi-Aventis Deutschland GmbH
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- Koehler, Sascha (author)
- Bruker BioSpin GmbH, Germany,Bruker BioSpin MRI GmbH
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- Lloyd, William (author)
- University of Manchester
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- Luo, Yanping (author)
- AbbVie,AbbVie Inc.
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- Mahmutovic Persson, Irma (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups
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- O'Connor, James P.B. (author)
- University of Manchester
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- Olsson, Lars E. (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups
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- Pindoria, Kashmira (author)
- GlaxoSmithKline,SmithKline Beecham Pharmaceuticals
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- Schneider, Jurgen E. (author)
- University of Leeds
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- Sourbron, Steven (author)
- University of Leeds
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- Steinmann, Denise (author)
- Sanofi-Aventis Deutschland GmbH
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- Strobel, Klaus (author)
- Bruker BioSpin GmbH, Germany,Bruker BioSpin MRI GmbH
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- Tadimalla, Sirisha (author)
- University of Leeds
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- Teh, Irvin (author)
- University of Leeds
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- Veltien, Andor (author)
- Radboud Universiteit,Radboud University,Radboud University Medical Center
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- Zhang, Xiaomeng (author)
- AbbVie,AbbVie Inc.
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- Schütz, Gunnar (author)
- Bayer AG,Bayer Pharma AG
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Magnetic Resonance Imaging. - : Elsevier BV. - 1873-5894 .- 0730-725X. ; 59, s. 121-129
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Abstract
Subject headings
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- Background: Many translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R 1 , but evidence for between-site reproducibility of R 1 in small-animal MRI is lacking. Objective: To assess R 1 repeatability and multi-site reproducibility in phantoms for preclinical MRI. Methods: R 1 was measured by saturation recovery in 2% agarose phantoms with five nickel chloride concentrations in 12 magnets at 5 field strengths in 11 centres on two different occasions within 1–13 days. R 1 was analysed in three different regions of interest, giving 360 measurements in total. Root-mean-square repeatability and reproducibility coefficients of variation (CoV) were calculated. Propagation of reproducibility errors into 21 translational MR measurements and biomarkers was estimated. Relaxivities were calculated. Dynamic signal stability was also measured. Results: CoV for day-to-day repeatability (N = 180 regions of interest) was 2.34% and for between-centre reproducibility (N = 9 centres) was 1.43%. Mostly, these do not propagate to biologically significant between-centre error, although a few R 1 -based MR biomarkers were found to be quite sensitive even to such small errors in R 1 , notably in myocardial fibrosis, in white matter, and in oxygen-enhanced MRI. The relaxivity of aqueous Ni 2+ in 2% agarose varied between 0.66 s −1 mM −1 at 3 T and 0.94 s −1 mM −1 at 11.7T. Interpretation: While several factors affect the reproducibility of R 1 -based MR biomarkers measured preclinically, between-centre propagation of errors arising from intrinsic equipment irreproducibility should in most cases be small. However, in a few specific cases exceptional efforts might be required to ensure R 1 -reproducibility.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk apparatteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Equipment Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Keyword
- Phantom
- Relaxation time
- Reproducibility
- Biomarker
- MRI
- Hardware stability
- Error propagation
- Biomarker
- Error propagation
- Hardware stability
- MRI
- Phantom
- Relaxation time
- Reproducibility
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Waterton, John C ...
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Hines, Catherine ...
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Hockings, Paul, ...
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Laitinen, Iina
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Ziemian, Sabina
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Campbell, Simon
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show more...
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Gottschalk, Mich ...
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Green, Claudia
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Haase, Michael
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Hassemer, Katja
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Juretschke, Hans ...
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Koehler, Sascha
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Lloyd, William
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Luo, Yanping
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Mahmutovic Perss ...
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O'Connor, James ...
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Olsson, Lars E.
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Pindoria, Kashmi ...
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Schneider, Jurge ...
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Sourbron, Steven
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Steinmann, Denis ...
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Strobel, Klaus
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Tadimalla, Siris ...
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Teh, Irvin
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Veltien, Andor
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Zhang, Xiaomeng
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Schütz, Gunnar
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Equipmen ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
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Magnetic Resonan ...
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Chalmers University of Technology
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Lund University