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Pre-diagnostic plas...
Pre-diagnostic plasma enterolactone concentrations are associated with lower mortality among individuals with type 2 diabetes: a case-cohort study in the Danish Diet, Cancer and Health cohort
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- Eriksen, Anne K. (författare)
- Danish Cancer Research Society Center, Denmark
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- Kyro, C. (författare)
- Danish Cancer Research Society Center, Denmark
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- Nørskov, N. (författare)
- Århus Universitet,Aarhus University
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- Frederiksen, Kirsten (författare)
- Danish Cancer Research Society Center, Denmark
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- Bach Knudsen, Knud Erik (författare)
- Århus Universitet,Aarhus University
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- Overvad, K. (författare)
- Århus Universitet,Aarhus University
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- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Tjønneland, Anne (författare)
- Danish Cancer Research Society Center, Denmark,Köpenhamns universitet,University of Copenhagen
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- Olsen, Anja (författare)
- Danish Cancer Research Society Center, Denmark
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(creator_code:org_t)
- 2019-04-08
- 2019
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 62:6, s. 959-969
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: The phytoestrogen enterolactone is a gut microbiota-derived metabolite of plant lignans with suggested beneficial properties for health. In the current study, we investigated the association between pre-diagnostic plasma enterolactone concentrations and mortality among individuals diagnosed with type 2 diabetes. Methods: In a population of people diagnosed with diabetes, nested within the Danish Diet, Cancer and Health cohort, we conducted a case-cohort study including a random sample of n = 450 cases (deceased) and a randomly selected subcohort of n = 850 (in total n = 617 deaths). Information on diagnosis, vital status and cause of death was obtained from Danish registers. Cox proportional hazard models with special weighting were applied to assess all-cause and cause-specific mortality. Results: The median enterolactone concentration of the current population was low, 10.9 nmol/l (5th percentile to 95th percentile: 1.3–59.6), compared with previously reported concentrations from the Diet, Cancer and Health cohort. Pre-diagnostic enterolactone concentrations were associated with lower all-cause mortality when assessed linearly per doubling in concentration (log 2 ) (HR 0.91 [95% CI 0.85, 0.96]) and according to quartiles (HR 0.63 [95% CI 0.48, 0.84]) for the highest quartile of enterolactone compared with the lowest quartile. For cause-specific mortality, only death from diabetes (registered as underlying cause of death) reached statistical significance. Conclusions/interpretation: Based on this large cohort of people with diabetes with detailed and complete baseline and follow-up information, pre-diagnostic enterolactone concentrations were inversely associated with mortality. To our knowledge, this is the first study on enterolactone and type 2 diabetes mortality. Our findings call for further exploration of enterolactone in type 2 diabetes management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Mortality
- Type 2 diabetes
- Prognosis
- Enterolactone
- Case-cohort
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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