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Metabolome biomarke...
Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
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- Unión-Caballero, Andrea (författare)
- Universitat de Barcelona,University of Barcelona
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- Meroño, Tomás (författare)
- Universitat de Barcelona,University of Barcelona
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Zamora-Ros, Raul (författare)
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- Rostgaard-Hansen, Agneta (författare)
- Danish Cancer Research Society Center, Denmark
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- Miñarro, Antonio (författare)
- Universitat de Barcelona,University of Barcelona
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- Sánchez-Pla, Alex (författare)
- Universitat de Barcelona,University of Barcelona
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- Estanyol-Torres, Núria (författare)
- Universitat de Barcelona,University of Barcelona
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- Martínez-Huelamo, Miriam (författare)
- Universitat de Barcelona,University of Barcelona
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- Cubedo, Marta (författare)
- Universitat de Barcelona,University of Barcelona
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- González-Domínguez, Raúl (författare)
- Universitat de Barcelona,University of Barcelona
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- Tjønneland, Anne (författare)
- Danish Cancer Research Society Center, Denmark
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- Riccardi, Gabrielle (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Halkjær, Jytte (författare)
- Danish Cancer Research Society Center, Denmark
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- Andres-Lacueva, Cristina (författare)
- Universitat de Barcelona,University of Barcelona
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Food and Function. - 2042-6496 .- 2042-650X. ; 15:3, s. 1643-1654
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic risk factors. We used data and samples from the Danish Diet Cancer and Health Next Generation (DCH-NG) MAX-study, a one-year observational study with evaluations at baseline, six and 12 months (n = 624, 55% female, mean age: 43 years, 1353 observations). Direct associations between fibre intake and plasma concentrations of 2,6-dihydroxybenzoic acid (2,6-DHBA) and indolepropionic acid were observed at the three time-points. Both metabolites showed an intraclass-correlation coefficient (ICC) > 0.50 and were associated with the self-reported intake of wholegrain cereals, and of fruits and vegetables, respectively. Other metabolites associated with dietary fibre intake were linolenoyl carnitine, 2-aminophenol, 3,4-DHBA, and proline betaine. Based on the metabolites associated with dietary fibre intake we calculated predicted values of fibre intake using a multivariate, machine-learning algorithm. Metabolomics-based predicted fibre, but not self-reported fibre values, showed negative associations with cardiometabolic risk factors (i.e. high sensitivity C-reactive protein, systolic and diastolic blood pressure, all FDR-adjusted p-values <0.05). Furthermore, different correlations with gut microbiota composition were observed. In conclusion, 2,6-DHBA and indolepropionic acid in plasma may better link dietary fibre intake with its metabolic effects than self-reported values. These metabolites may represent a novel class of biomarkers reflecting both dietary exposure and host and/or gut microbiota characteristics providing a read-out that is differentially related to cardiometabolic risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
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Unión-Caballero, ...
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Meroño, Tomás
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Zamora-Ros, Raul
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Rostgaard-Hansen ...
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Miñarro, Antonio
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Sánchez-Pla, Ale ...
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visa fler...
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Estanyol-Torres, ...
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Martínez-Huelamo ...
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Cubedo, Marta
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González-Domíngu ...
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Tjønneland, Anne
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Riccardi, Gabrie ...
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Landberg, Rikard ...
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Halkjær, Jytte
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Andres-Lacueva, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Food and Functio ...
- Av lärosätet
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Chalmers tekniska högskola