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A Systematic Invest...
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome
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- Robinson, Jonathan, 1986 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, Gothenburg, Sweden.;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, Gothenburg, Sweden.
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- Feizi, Amir, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, Gothenburg, Sweden.;Novo Nordisk Res Ctr Oxford, Old Campus Rd, Oxford, England.
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- Uhlén, Mathias (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Nielsen, Jens B, 1962 (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, Gothenburg, Sweden ; Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, Gothenburg, Sweden ; Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, DK-2800 Lyngby, Denmark
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Chalmers tekniska högskola Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, Gothenburg, Sweden;Chalmers Univ Technol, Wallenberg Ctr Prot Res, Kemivagen 10, Gothenburg, Sweden. (creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 26:10, s. 2622-2635.e5
- Relaterad länk:
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https://research.cha... (primary) (free)
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http://www.cell.com/...
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The collection of proteins secreted from a cell—the secretome—is of particular interest in cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However, cancer secretome studies are often limited to one tissue or cancer type or focus on biomarker prediction without exploring the associated functions. We therefore conducted a pan-cancer analysis of secretome gene expression changes to identify candidate diagnostic biomarkers and to investigate the underlying biological function of these changes. Using transcriptomic data spanning 32 cancer types and 30 healthy tissues, we quantified the relative diagnostic potential of secretome proteins for each cancer. Furthermore, we offer a potential mechanism by which cancer cells relieve secretory pathway stress by decreasing the expression of tissue-specific genes, thereby facilitating the secretion of proteins promoting invasion and proliferation. These results provide a more systematic understanding of the cancer secretome, facilitating its use in diagnostics and its targeting for therapeutic development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cancer biomarkers
- pan-cancer
- protein secretion
- systems biology
- secretome
- unfolded protein response
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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