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Intramuscular Stimu...
Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients
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- Pascual-Valdunciel, Alejandro (författare)
- CSIC - Instituto Cajal (IC),Cajal Institute,Universidad Politecnica de Madrid,Technical University of Madrid
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- Gonzalez-Sanchez, Miguel (författare)
- Hospital General Universitario Gregorio Maranon
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- Muceli, Silvia, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Adan-Barrientos, Beatriz (författare)
- Universidad Carlos Iii De Madrid
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- Escobar-Segura, Viviana (författare)
- Universidad Complutense de Madrid,Complutense University
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- Perez-Sanchez, Javier Ricardo (författare)
- Hospital General Universitario Gregorio Maranon
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- Jung, Moon Ki (författare)
- Imperial College of Science, Technology and Medicine
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- Schneider, Andreas (författare)
- Fraunhofer-Institut fur Biomedizinische Technik (IBMT),Fraunhofer Institute for Biomedical Engineering (IBMT)
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- Hoffmann, Klaus Peter (författare)
- Fraunhofer-Institut fur Biomedizinische Technik (IBMT),Fraunhofer Institute for Biomedical Engineering (IBMT)
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- Moreno, Juan Camilo (författare)
- CSIC - Instituto Cajal (IC),Cajal Institute
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- Grandas, Francisco (författare)
- Hospital General Universitario Gregorio Maranon,Universidad Complutense de Madrid,Complutense University
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- Farina, Dario (författare)
- Imperial College of Science, Technology and Medicine
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- Pons, Jose L. (författare)
- CSIC - Instituto Cajal (IC),Cajal Institute,Northwestern University
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- Barroso, Filipe O. (författare)
- CSIC - Instituto Cajal (IC),Cajal Institute
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(creator_code:org_t)
- 2021
- 2021
- Engelska.
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Ingår i: IEEE Transactions on Biomedical Engineering. - 0018-9294 .- 1558-2531. ; 68:6, s. 1768-1776
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This study proposes and clinically tests intramuscular electrical stimulation below motor threshold to achieve prolonged reduction of wrist flexion/extension tremor in Essential Tremor (ET) patients. The developed system consisted of an intramuscular thin-film electrode structure that included both stimulation and electromyography (EMG) recording electrodes, and a control algorithm for the timing of intramuscular stimulation based on EMG (closed-loop stimulation). Data were recorded from nine ET patients with wrist flexion/extension tremor recruited from the Gregorio Marañón Hospital (Madrid, Spain). Patients participated in two experimental sessions comprising: 1) sensory stimulation of wrist flexors/extensors via thin-film multichannel intramuscular electrodes; and 2) surface stimulation of the nerves innervating the same target muscles. For each session, four of these patients underwent random 60-s trials of two stimulation strategies for each target muscle: 1) selective and adaptive timely stimulation (SATS) - based on EMG of the antagonist muscle; and 2) continuous stimulation (CON) of target muscles. Two patients underwent SATS stimulation trials alone while the other three underwent CON stimulation trials alone in each session. Kinematics of wrist, elbow, and shoulder, together with clinical scales, were used to assess tremor before, right after, and 24 h after each session. Intramuscular SATS achieved, on average, 32% acute (during stimulation) tremor reduction on each trial, while continuous stimulation augmented tremorgenic activity. Furthermore, tremor reduction was significantly higher using intramuscular than surface stimulation. Prolonged reduction of tremor amplitude (24 h after the experiment) was observed in four patients. These results showed acute and prolonged (24 h) tremor reduction using a minimally invasive neurostimulation technology based on SATS of primary sensory afferents of wrist muscles. This strategy might open the possibility of an alternative therapeutic approach for ET patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Intramuscular
- Tremor reduction
- Essential tremor
- Neuromodulation
- Sensory stimulation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Pascual-Valdunci ...
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Gonzalez-Sanchez ...
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Muceli, Silvia, ...
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Adan-Barrientos, ...
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Escobar-Segura, ...
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Perez-Sanchez, J ...
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Jung, Moon Ki
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Schneider, Andre ...
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Hoffmann, Klaus ...
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Moreno, Juan Cam ...
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Grandas, Francis ...
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Farina, Dario
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Pons, Jose L.
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Barroso, Filipe ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oto rhino laryng ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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IEEE Transaction ...
- Av lärosätet
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Chalmers tekniska högskola