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In vitro and in viv...
In vitro and in vivo response to nanotopographically-modified surfaces of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone.
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Giavaresi, Gianluca (författare)
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Tschon, Matilde (författare)
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- Daly, John H (författare)
- University of Strathclyde
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visa fler...
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- Liggat, John J (författare)
- University of Strathclyde
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- Sutherland, Duncan, 1970 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Agheli, Hossein, 1965 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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Fini, Milena (författare)
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Torricelli, Paola (författare)
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Giardino, Roberto (författare)
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visa färre...
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(creator_code:org_t)
- Informa UK Limited, 2006
- 2006
- Engelska.
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Ingår i: Journal of Biomaterials Science, Polymer Edition. - : Informa UK Limited. - 0920-5063 .- 1568-5624. ; 17:12, s. 1405-23
- Relaterad länk:
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http://dx.doi.org/10...
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https://research.cha...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Colloidal lithography and embossing master are new techniques of producing nanotopography, which have been recently applied to improve tissue response to biomaterials by modifying the surface topography on a nano-scale dimension. A natural polyester (Biopol), 8% 3-hydroxyvalerate-component (D400G) and a conventional biodegradable polycaprolactone (PCL) were studied, both nanostructured and native forms, in vitro and in vivo. Nanopits (100-nm deep, 120-nm diameter) on the D400G surface were produced by the embossing master technique (Nano-D400G), while nanocylinders (160-nm height, 100-nm diameter) on the PCL surface were made by the colloidal lithography technique (Nano-PCL). L929 fibroblasts were seeded on polyesters, and cell proliferation, cytotoxic effect, synthetic and cytokine production were assessed after 72 h and 7 days. Then, under general anesthesia, 3 Sprague-Dawley rats received dorsal subcutaneous implants of nanostructured and native polyesters. At 1, 4 and 12 weeks the animals were pharmacologically euthanized and implants with surrounding tissue studied histologically and histomorphometrically. In vitro results showed significant differences between D400G and PCL in Interleukin-6 production at 72 h. At 7 days, significant (P
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies (hsv//eng)
Nyckelord
- Experimental
- Inflammation
- Rats
- Animals
- standards
- Neovascularization
- Cytokines
- Implants
- Fibroblasts
- Cell Survival
- Cell Proliferation
- Blood Vessels
- biosynthesis
- Polyesters
- Time Factors
- Surface Properties
- chemistry
- Biocompatible Materials
- Mice
- Rats
- methods
- cytology
- chemistry
- Physiologic
- Sprague-Dawley
- Tissue Engineering
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Giavaresi, Gianl ...
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Tschon, Matilde
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Daly, John H
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Liggat, John J
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Sutherland, Dunc ...
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Agheli, Hossein, ...
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visa fler...
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Fini, Milena
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Torricelli, Paol ...
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Giardino, Robert ...
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Annan teknik
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Journal of Bioma ...
- Av lärosätet
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Chalmers tekniska högskola