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Plasma metabolomic ...
Plasma metabolomic profiles of plant-based dietary indices reveal potential pathways for metabolic syndrome associations
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- Lanuza, Fabian (författare)
- Universitat de Barcelona,University of Barcelona
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- Meroño, Tomás (författare)
- Universitat de Barcelona,University of Barcelona
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- Zamora-Ros, Raul (författare)
- Universitat de Barcelona,University of Barcelona
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- Bondonno, Nicola P. (författare)
- Danish Cancer Research Society Center, Denmark,Edith Cowan University
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- Rostgaard-Hansen, Agneta (författare)
- Danish Cancer Research Society Center, Denmark
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- Sánchez-Pla, Alex (författare)
- Universitat de Barcelona,University of Barcelona
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- Miro, Berta (författare)
- Universitat de Barcelona,University of Barcelona
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- Carmona-Pontaque, Francesc (författare)
- Universitat de Barcelona,University of Barcelona
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- Riccardi, Gabriele (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Tjønneland, Anne (författare)
- Danish Cancer Research Society Center, Denmark
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- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Halkjær, Jytte (författare)
- Danish Cancer Research Society Center, Denmark
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- Andres-Lacueva, Cristina (författare)
- Universitat de Barcelona,University of Barcelona
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Atherosclerosis. - 1879-1484 .- 0021-9150. ; 382
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and aims: Plant-based dietary patterns have been associated with improved health outcomes. This study aims to describe the metabolomic fingerprints of plant-based diet indices (PDI) and examine their association with metabolic syndrome (MetS) and its components in a Danish population. Methods: The MAX study comprised 676 participants (55% women, aged 18-67 y) from Copenhagen. Sociodemographic and dietary data were collected using questionnaires and three 24-h dietary recalls over one year (at baseline, and at 6 and 12 months). Mean dietary intakes were computed, as well as overall PDI, healthful (hPDI) and unhealthful (uPDI) scores, according to food groups for each plant-based index. Clinical variables were also collected at the same time points in a health examination that included complete blood tests. MetS was defined according to the International Diabetes Federation criteria. Plasma metabolites were measured using a targeted metabolomics approach. Metabolites associated with PDI were selected using random forest models and their relationships with PDIs and MetS were analyzed using generalized linear mixed models. Results: The mean prevalence of MetS was 10.8%. High, compared to low, hPDI and uPDI scores were associated with a lower and higher odd of MetS, respectively [odds ratio (95%CI); hPDI: 0.56 (0.43–0.74); uPDI: 1.61 (1.26–2.05)]. Out of 411 quantified plasma metabolites, machine-learning metabolomics fingerprinting revealed 13 metabolites, including food and food-related microbial metabolites, like hypaphorine, indolepropionic acid and lignan-derived enterolactones. These metabolites were associated with all PDIs and were inversely correlated with MetS components (p < 0.05). Furthermore, they had an explainable contribution of 12% and 14% for the association between hPDI or uPDI, respectively, and MetS only among participants with overweight/obesity. Conclusions: Metabolites associated with PDIs were inversely associated with MetS and its components, and may partially explain the effects of plant-based diets on cardiometabolic risk factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Metabolomics
- Metabolic syndromes
- Cardiovascular risk factors
- Plant-based diet
- Indolepropionic
- Dietary patterns
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Lanuza, Fabian
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Meroño, Tomás
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Zamora-Ros, Raul
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Bondonno, Nicola ...
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Rostgaard-Hansen ...
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Sánchez-Pla, Ale ...
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Miro, Berta
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Carmona-Pontaque ...
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Riccardi, Gabrie ...
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Tjønneland, Anne
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Landberg, Rikard ...
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Halkjær, Jytte
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Andres-Lacueva, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Atherosclerosis
- Av lärosätet
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Chalmers tekniska högskola