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Effects of a Vegeta...
Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover Study
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- Djekic, Demir, 1989- (författare)
- Örebro läns landsting,Department of Cardiology, Faculty of Health, Örebro University Hospital, Örebro, Sweden
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- Shi, Lin, 1988 (författare)
- Shaanxi Normal University,Chalmers tekniska högskola,Chalmers University of Technology,Engineering and Nutritional Science, Shaanxi Normal University, Xi'an China; Chalmers University of Technology, Gothenburg, Sweden
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- Brolin, Harald (författare)
- The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
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- Carlsson, Frida, 1983 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden
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- Särnqvist, Charlotte (författare)
- Örebro läns landsting,Department of Cardiology, Faculty of Health, Örebro University Hospital, Örebro, Sweden
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- Savolainen, Otto, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden
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- Cao, Yang, Associate Professor, 1972- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics,Örebro University
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- Bäckhed, Fredrik, 1973 (författare)
- Köpenhamns universitet,University of Copenhagen,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Clinical Physiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Tremaroli, Valentina, 1978 (författare)
- The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
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- Landberg, Rikard, 1981 (författare)
- Umeå universitet,Kardiologi,Chalmers University of Technology, Gothenburg, Sweden,Chalmers tekniska högskola,Umeå University
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University Hospital, Örebro, Sweden,Örebro läns landsting
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(creator_code:org_t)
- Wiley-Blackwell Publishing Inc. 2020
- 2020
- Engelska.
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Ingår i: Journal of the American Heart Association. - : Wiley-Blackwell Publishing Inc.. - 2047-9980. ; 9:18, s. e016518-e016518
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Abstract
Ämnesord
Stäng
- Background A vegetarian diet (VD) may reduce future cardiovascular risk in patients with ischemic heart disease. Methods and Results A randomized crossover study was conducted in subjects with ischemic heart disease, assigned to 4-week intervention periods of isocaloric VD and meat diet (MD) with individually designed diet plans, separated by a 4-week washout period. The primary outcome was difference in oxidized low-density lipoprotein cholesterol (LDL-C) between diets. Secondary outcomes were differences in cardiometabolic risk factors, quality of life, gut microbiota, fecal short-chain and branched-chain fatty acids, and plasma metabolome. Of 150 eligible patients, 31 (21%) agreed to participate, and 27 (87%) participants completed the study. Mean oxidized LDL-C (-2.73 U/L), total cholesterol (-5.03 mg/dL), LDL-C (-3.87 mg/dL), and body weight (-0.67 kg) were significantly lower with the VD than with the MD. Differences between VD and MD were observed in the relative abundance of several microbe genera within the families Ruminococcaceae, Lachnospiraceae, and Akkermansiaceae. Plasma metabolites, including l-carnitine, acylcarnitine metabolites, and phospholipids, differed in subjects consuming VD and MD. The effect on oxidized LDL-C in response to the VD was associated with a baseline gut microbiota composition dominated by several genera of Ruminococcaceae. Conclusions The VD in conjunction with optimal medical therapy reduced levels of oxidized LDL-C, improved cardiometabolic risk factors, and altered the relative abundance of gut microbes and plasma metabolites in patients with ischemic heart disease. Our results suggest that composition of the gut microbiota at baseline may be related to the reduction of oxidized LDL-C observed with the VD. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT02942628.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- gut microbiota
- coronary artery disease
- trimethylamine N-oxide
- vegetarian diet
- plasma metabolome
- randomized controlled trial
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Djekic, Demir, 1 ...
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Shi, Lin, 1988
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Brolin, Harald
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Carlsson, Frida, ...
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Särnqvist, Charl ...
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Savolainen, Otto ...
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Cao, Yang, Assoc ...
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Bäckhed, Fredrik ...
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Tremaroli, Valen ...
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Landberg, Rikard ...
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Fröbert, Ole, 19 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Annan klinisk me ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of the A ...
- Av lärosätet
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Chalmers tekniska högskola
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Örebro universitet
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Umeå universitet
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Karolinska Institutet