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Microporous bacteri...
Microporous bacterial cellulose as a potential scaffold for bone regeneration
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- Zaborowska, Magdalena, 1984 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Bodin, Aase Katarina, 1977 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Bäckdahl, Henrik, 1977 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Popp, J. (författare)
- Virginia Polytechnic Institute and State University (Virginia Tech)
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- Goldstein, A. (författare)
- Virginia Polytechnic Institute and State University (Virginia Tech)
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- Gatenholm, Paul, 1956 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 6:7, s. 2540-2547
- Relaterad länk:
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http://dx.doi.org/10...
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https://vtechworks.l...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Nanoporous cellulose biosynthesized by bacteria is an attractive biomaterial scaffold for tissue engineering due to its biocompatibility and good mechanical properties. However, for bone applications a microscopic pore structure is needed to facilitate osteoblast ingrowth and formation of a mineralized tissue. Therefore, in this study microporous bacterial cellulose (BC) scaffolds were prepared by incorporating 300-500 mu m paraffin wax microspheres into the fermentation process. The paraffin wax microspheres were subsequently removed, and scanning electron microscopy confirmed a microporous surface of the scaffolds while Fourier transform infrared spectroscopy verified the elimination of paraffin and tensile measurements showed a Young's modulus of approximately 1.6 MPa. Microporous BC and nanoporous (control) BC scaffolds were seeded with MC3T3-E1 osteoprogenitor cells, and examined by confocal microscopy and histology for cell distribution and mineral deposition. Cells clustered within the pores of microporous BC, and formed denser mineral deposits than cells grown on control BC surfaces. This work shows that microporous BC is a promising biomaterial for bone tissue engineering applications. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- biomimetic synthesis
- differentiation
- Bacterial cellulose
- biomaterials
- Mineralization
- Porogen
- Bone tissue engineering
- proliferation
- MC3T3-E1
- cells
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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