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Discordance between...
Discordance between mean glucose and time in range in relation to HbA 1c in individuals with type 1 diabetes: results from the GOLD and SILVER trials
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- Sterner Isaksson, Sofia (författare)
- Göteborgs universitet,University of Gothenburg,NU-sjukvården,NU Hospital Group,Univ Gothenburg, Sweden; NU Hosp Grp, Sweden
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- Imberg, Henrik, 1991 (författare)
- Göteborgs universitet,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Univ Gothenburg, Sweden; Chalmers Univ Technol, Sweden; Univ Gothenburg, Sweden; Statist Konsultgruppen, Sweden
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- Hirsch, Irl B. (författare)
- Univ Washington, WA USA
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- Schwarcz, Erik (författare)
- Orebro Univ, Sweden
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- Hellman, Jarl (författare)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden
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- Wijkman, Magnus (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN
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- Bolinder, Jan (författare)
- Karolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp Huddinge, Sweden
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- Nyström, Thomas (författare)
- Karolinska Institutet
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- Holmer, Helene (författare)
- Centralsjukhuset Kristianstad,Kristianstad Central Hospital,Dept Med, Sweden
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- Hallström, Sara (författare)
- Göteborgs universitet,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Ólafsdóttir, Arndís F. (författare)
- Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden
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- Pekkari, Sofia (författare)
- NU-sjukvården,NU Hospital Group,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden; NU Hosp Grp, Sweden
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- Polonsky, William (författare)
- Behav Diabet Inst, CA USA
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- Lind, Marcus, 1976 (författare)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,NU-sjukvården,NU Hospital Group,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden; NU Hosp Grp, Sweden; Sahlgrens Univ Hosp, Sweden
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(creator_code:org_t)
- SPRINGER, 2024
- 2024
- Engelska.
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Ingår i: Diabetologia. - : SPRINGER. - 1432-0428 .- 0012-186X. ; In Press
- Relaterad länk:
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: Previous studies have shown that individuals with similar mean glucose levels (MG) or percentage of time in range (TIR) may have different HbA1c values. The aim of this study was to further elucidate how MG and TIR are associated with HbA1c. Methods: Data from the randomised clinical GOLD trial (n=144) and the follow-up SILVER trial (n=98) of adults with type 1 diabetes followed for 2.5 years were analysed. A total of 596 paired HbA1c/continuous glucose monitoring measurements were included. Linear mixed-effects models were used to account for intra-individual correlations in repeated-measures data. Results: In the GOLD trial, the mean age of the participants (± SD) was 44±13 years, 63 (44%) were female, and the mean HbA1c (± SD) was 72±9.8 mmol/mol (8.7±0.9%). When correlating MG with HbA1c, MG explained 63% of the variation in HbA1c (r=0.79, p<0.001). The variation in HbA1c explained by MG increased to 88% (r=0.94, p value for improvement of fit <0.001) when accounting for person-to-person variation in the MG–HbA1c relationship. Time below range (TBR; <3.9 mmol/l), time above range (TAR) level 2 (>13.9 mmol/l) and glycaemic variability had little or no effect on the association. For a given MG and TIR, the HbA1c of 10% of individuals deviated by >8 mmol/mol (0.8%) from their estimated HbA1c based on the overall association between MG and TIR with HbA1c. TBR and TAR level 2 significantly influenced the association between TIR and HbA1c. At a given TIR, each 1% increase in TBR was related to a 0.6 mmol/mol lower HbA1c (95% CI 0.4, 0.9; p<0.001), and each 2% increase in TAR level 2 was related to a 0.4 mmol/mol higher HbA1c (95% CI 0.1, 0.6; p=0.003). However, neither TIR, TBR nor TAR level 2 were significantly associated with HbA1c when accounting for MG. Conclusions/interpretation: Inter-individual variations exist between MG and HbA1c, as well as between TIR and HbA1c, with clinically important deviations in relatively large groups of individuals with type 1 diabetes. These results may provide important information to both healthcare providers and individuals with diabetes in terms of prognosis and when making diabetes management decisions. Graphical Abstract: (Figure presented.).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Time in range
- Continuous glucose monitoring
- HbA 1c
- Type 1 diabetes
- Mean glucose
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sterner Isaksson ...
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Imberg, Henrik, ...
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Hirsch, Irl B.
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Schwarcz, Erik
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Hellman, Jarl
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Wijkman, Magnus
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Bolinder, Jan
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Nyström, Thomas
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Holmer, Helene
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Hallström, Sara
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Ólafsdóttir, Arn ...
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Pekkari, Sofia
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Polonsky, Willia ...
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Lind, Marcus, 19 ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Chalmers tekniska högskola
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Linköpings universitet
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Karolinska Institutet