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Comprehensive analy...
Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass
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- Titova, Olga E. (författare)
- Uppsala universitet,Medicinsk epidemiologi,Uppsala University
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- Brunius, Carl, 1974 (författare)
- Uppsala universitet,Medicinsk epidemiologi,Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology,Uppsala University
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- Warensjö Lemming, Eva, Associate Professor, 1973- (författare)
- Uppsala universitet,Medicinsk epidemiologi,Institutionen för kostvetenskap,Department of Food studies, nutrition and dietetics, Uppsala University, Uppsala, Sweden.,Uppsala University
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- Stattin, Karl (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala University
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- Baron, John A. (författare)
- Uppsala universitet,Medicinsk epidemiologi,Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.,The University of North Carolina,The University of North Carolina System,Uppsala University
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- Byberg, Liisa (författare)
- Uppsala universitet,Medicinsk epidemiologi,Uppsala University
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- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Medicinsk epidemiologi,Uppsala University
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.,Uppsala University
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Obesity. - : Springer Nature. - 1476-5497 .- 0307-0565. ; 47:11, s. 1043-1049
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Abstract
Ämnesord
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- Background: The underlying molecular pathways for the effect of excess fat mass on cardiometabolic diseases is not well understood. Since body mass index is a suboptimal measure of body fat content, we investigated the relationship of fat mass measured by dual-energy X-ray absorptiometry with circulating cardiometabolic proteins. Methods: We used data from a population-based cohort of 4950 Swedish women (55–85 years), divided into discovery and replication samples; 276 proteins were assessed with three Olink Proseek Multiplex panels. We used random forest to identify the most relevant biomarker candidates related to fat mass index (FMI), multivariable linear regression to further investigate the associations between FMI characteristics and circulating proteins adjusted for potential confounders, and principal component analysis (PCA) for the detection of common covariance patterns among the proteins. Results: Total FMI was associated with 66 proteins following adjustment for multiple testing in discovery and replication multivariable analyses. Five proteins not previously associated with body size were associated with either lower FMI (calsyntenin-2 (CLSTN2), kallikrein-10 (KLK10)), or higher FMI (scavenger receptor cysteine-rich domain-containing group B protein (SSC4D), trem-like transcript 2 protein (TLT-2), and interleukin-6 receptor subunit alpha (IL-6RA)). PCA provided an efficient summary of the main variation in FMI-related circulating proteins involved in glucose and lipid metabolism, appetite regulation, adipocyte differentiation, immune response and inflammation. Similar patterns were observed for regional fat mass measures. Conclusions: This is the first large study showing associations between fat mass and circulating cardiometabolic proteins. Proteins not previously linked to body size are implicated in modulation of postsynaptic signals, inflammation, and carcinogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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