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Mind the gap - defi...
Mind the gap - deficits in our knowledge of aspects impacting bioavailability of phytochemicals and their metabolites - a position paper focusing on carotenoids and polyphenols
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- Bohn, T. (författare)
- Luxembourg Institute of Science and Technology
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- McDougall, Gordon J. (författare)
- The James Hutton Institute
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- Alegria, Amparo (författare)
- Universitat de Valencia
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- Alminger, Marie, 1957 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Arrigoni, Eva (författare)
- Forschungsanstalt Agroscope Changins-Wadenswil
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- Aura, Anna-Marja (författare)
- Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT)
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- Brito, Catarina (författare)
- Nova University of Lisbon, Portugal,Instituto de Biologia Experimental e Tecnologica
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- Cilla, Antonio (författare)
- Universitat de Valencia
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- El, Sedef N. (författare)
- Ege Universitesi,Ege University
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- Karakaya, S. (författare)
- Ege Universitesi,Ege University
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- Martinez-Cuesta, Marie C. (författare)
- Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL)
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- Santos, C. N. (författare)
- Nova University of Lisbon, Portugal,Instituto de Biologia Experimental e Tecnologica
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(creator_code:org_t)
- 2015-06-03
- 2015
- Engelska.
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Ingår i: Molecular Nutrition and Food Research. - : Wiley. - 1613-4133 .- 1613-4125. ; 59:7, s. 1307-13231-17-1323
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardiovascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammatory and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose and host related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Microbiota
- Food processing
- Mixed diet
- Biotransformation
- Transporters
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Till lärosätets databas
- Av författaren/redakt...
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Bohn, T.
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McDougall, Gordo ...
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Alegria, Amparo
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Alminger, Marie, ...
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Arrigoni, Eva
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Aura, Anna-Marja
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visa fler...
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Brito, Catarina
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Cilla, Antonio
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El, Sedef N.
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Karakaya, S.
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Martinez-Cuesta, ...
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Santos, C. N.
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Annan teknik
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Annan kemi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Molecular Nutrit ...
- Av lärosätet
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Chalmers tekniska högskola