Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D

• Objective: Elevated levels of calcium and parathyroid hormone (PTH), characteristics of primary hyperparathyroidism (PHPT), may be associated with cardiovascular morbidity and mortality in the general population. We evaluated the possible vascular effects of these risk factors in patients with mild PHPT by using standard methods and new imaging techniques.Design: A prospective case-control study.Subjects and Methods: Forty-eight patients with mild PHPT without any known cardiovascular risk factors were studied at baseline and at one year after parathyroidectomy (PTX) in comparison with 48 healthy age-and gender-matched controls. We measured biochemical variables, augmentation index (AIx), aortic pulse wave velocity (PWVao), radial (IMTrad) and common carotid artery (IMTcca) intima media thicknesses, and the grayscale median (IM-GSM) of the latter.Results: No significant differences were observed between PHPT patients and controls at baseline for AIx (28.6+/-12.2 vs. 27.7+/-12.8%), IMTrad (0.271+/-0.060 vs. 0.255+/-0.053 mm), IMTcca (0.688+/-0.113 vs. 0.680+/-0.135 mm), or IM-GSM (82.3+/-17.2 vs. 86.5+/-15.3), while PWVao was slightly higher in patients (8.68+/-1.50 vs. 8.13+/-1.55, p

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MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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