EXPERIMENTAL SEARCH FOR COMBINED AC AND DC MAGNETIC-FIELD EFFECTS ON ION CHANNELS

• The hypothesis that specific combinations of DC and low frequency AC magnetic fields at so-called cyclotron-resonance conditions could affect the transport of ions through ion channels, or alter the kinetics of ion channels (opening and closing rates), has been tested. As a model system, the ion channels formed by gramicidin A incorporated in lipid bilayer membranes were studied. No significant changes in channel conductance, average lifetime, or formation rate as a function of applied fields could be detected over a wide range of frequencies and field strengths. Experiments were carried out to measure the time-resolved single-channel events and the average conductances of many-channel events in the presence of K+ and H+ ions. The channel blocking effect of Ca++ was also studied. (C) 1993 Wiley-Liss, Inc.

Ämnesord

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

potassium ion

low-frequency

behavior

electric-fields

binding

cyclotron-resonance

brain-tissue invitro

gramicidin-a

radiation

cyclotron resonance

gramicidin

efflux

elf

bilayer membrane

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)