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Radiobiological eva...
Radiobiological evaluation of combined gamma knife radiosurgery and hyperthermia for pediatric neuro-oncology
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- Ghaderi Aram, Morteza, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Zanoli, Massimiliano, 1989 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nordström, Håkan (författare)
- Elekta AB
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- Toma-Dasu, Iuliana (författare)
- Stockholms universitet,Fysikum,Karolinska Institutet, Sweden,Karolinska universitetssjukhuset,Karolinska University Hospital,Stockholm University
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- Blomgren, K. (författare)
- Karolinska Institutet
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- Dobsicek Trefna, Hana, 1979 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2021-06-30
- 2021
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:13
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https://www.mdpi.com...
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https://doi.org/10.3...
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https://doi.org/10.3...
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https://research.cha...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Combining radiotherapy (RT) with hyperthermia (HT) has been proven effective in the treatment of a wide range of tumours, but the combination of externally delivered, focused heat and stereotactic radiosurgery has never been investigated. We explore the potential of such treatment enhancement via radiobiological modelling, specifically via the linear-quadratic (LQ) model adapted to thermoradiotherapy through modulating the radiosensitivity of temperature-dependent parame-ters. We extend this well-established model by incorporating oxygenation effects. To illustrate the methodology, we present a clinically relevant application in pediatric oncology, which is novel in two ways. First, it deals with medulloblastoma, the most common malignant brain tumour in children, a type of brain tumour not previously reported in the literature of thermoradiotherapy studies. Second, it makes use of the Gamma Knife for the radiotherapy part, thereby being the first of its kind in this context. Quantitative metrics like the biologically effective dose (BED) and the tumour control probability (TCP) are used to assess the efficacy of the combined plan.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Biological modelling
- Medulloblastoma
- Stereotactic radiotherapy
- Hyperthermia
- CNS tumors
- LQ model
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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