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Understanding the i...
Understanding the interactions between bacteria in the human gut through metabolic modeling
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- Shoaie, Saeed, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Karlsson, Fredrik, 1984 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mardinoglu, Adil, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Nookaew, Intawat, 1977 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Velasco, Sergio, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2013-08-28
- 2013
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 3
- Relaterad länk:
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http://publications.... (primary) (free)
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https://www.nature.c...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The human gut microbiome plays an influential role in maintaining human health, and it is a potential target for prevention and treatment of disease. Genome-scale metabolic models (GEMs) can provide an increased understanding of the mechanisms behind the effects of diet, the genotype-phenotype relationship and microbial robustness. Here we reconstructed GEMs for three key species, (Bacteroides thetaiotamicron, Eubacterium rectale and Methanobrevibacter smithii) as relevant representatives of three main phyla in the human gut (Bacteroidetes, Firmicutes and Euryarchaeota). We simulated the interactions between these three bacteria in different combinations of gut ecosystems and compared the predictions with the experimental results obtained from colonization of germ free mice. Furthermore, we used our GEMs for analyzing the contribution of each species to the overall metabolism of the gut microbiota based on transcriptome data and demonstrated that these models can be used as a scaffold for understanding bacterial interactions in the gut.
Ämnesord
- NATURVETENSKAP -- Annan naturvetenskap (hsv//swe)
- NATURAL SCIENCES -- Other Natural Sciences (hsv//eng)
Nyckelord
- MUTUALISM
- HEALTH
- METHANOBREVIBACTER-SMITHII
- NETWORK
- LARGE-INTESTINE
- HUMAN COLONIC MICROBIOTA
- METAGENOME
- ABSORPTION
- BUTYRATE
- DIET
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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