Investigation of diffuse axonal injury induced by rotational acceleration via numerical reconstructions of in vivo rat head impact experiments

• The purpose of this study is to investigate the brain-strain-based thresholds for better prediction of the diffuse axonal injury(DAI) induced by a rotational acceleration on the rat brain. A previously developed and validated rat head finite elementmodel was used to reconstruct 26 in vivo rat head impact experiments. DAI was produced via the high rotationalacceleration applied to the rat head on the sagittal plane. Intracranial strain and strain-based injury indexes were calculated,including the maximum principal strain (MPS), the product of strain and strain rate, and the cumulative strain damagemeasure (CSDM). The region-specific conservative thresholds for DAI were estimated in terms of strain and strain-basedinjury indexes in the frontal, middle, and occipital regions of the corpus callosum. The axonal injuries observed in theexperiments were used to formulate the injury risk functions, and the DAI risks were analysed via binary logisticregressions in terms of the calculated injury indexes. The logistic regression analysis demonstrated that the MPS, theproduct of strain and strain rate, as well as the CSDM were significantly correlated with DAI in the frontal corpuscallosum. For the 50% probability of DAI in the frontal corpus callosum, it is suggested that the strain-based threshold is0.12 for the MPS, 110 s¡1 for the product of strain and strain rate, and 17% for the CSDM.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Maskinteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Mechanical Engineering (hsv//eng)

Nyckelord

animal experiments

diffuse axonal injury

finite element simulation

traumatic brain injury

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art (ämneskategori)

ref (ämneskategori)