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Clinical Impression...
Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life
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- Norlin, Jenny M. (author)
- The Swedish Institute for Health Economics,Institutet För Hälso- Och Sjukvårdsekonomi,IHE – The Swedish Institute for Health Economics
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- Kellerborg, Klas (author)
- The Swedish Institute for Health Economics,Institutet För Hälso- Och Sjukvårdsekonomi,IHE – The Swedish Institute for Health Economics
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- Persson, Ulf (author)
- The Swedish Institute for Health Economics,Institutet För Hälso- Och Sjukvårdsekonomi,IHE – The Swedish Institute for Health Economics
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- Åström, Daniel Oudin (author)
- H. Lundbeck A/S
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- Hagell, Peter (author)
- Kristianstad University,Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Martinez-Martin, Pablo (author)
- Instituto de Salud Carlos III,Carlos III Health Institute
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- Odin, Per (author)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Swedish Parkinson Network (SWEPAR-net),Skåne University Hospital
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(creator_code:org_t)
- 2023-01-20
- 2022
- English.
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In: Movement Disorders Clinical Practice. - : John Wiley and Sons Ltd. - 2330-1619.
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD. Objective : To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire–8 [PDQ-8]) health-related quality of life assessments. Methods : Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept. Results : In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (rs = 0.60, rs = 0.54, rs = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (rs = 0.39, rs = 0.29) (P values < 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values < 0.001). Conclusions : The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- CISI-PD
- EQ-5D
- Parkinson's disease
- PDQ-8
Publication and Content Type
- ref (subject category)
- art (subject category)
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