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Smoking is associated with mosaic loss of chromosome Y

Dumanski, Jan P. (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
Rasi, Chiara (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
Lönn, Mikael (author)
Södertörns högskola,Biologi,Södertörn University, School of Life Sciences, Biology, Huddinge, Sweden,Södertörns högskola, Biologi,Södertörn University (SE)
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Davies, Hanna (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
Ingelsson, Martin (author)
Uppsala universitet,Geriatrik,Uppsala University,Uppsala University (SE)
Giedraitis, Vilmantas (author)
Uppsala universitet,Geriatrik,Uppsala University,Uppsala University (SE)
Lannfelt, Lars (author)
Karolinska Institutet,Uppsala universitet,Geriatrik,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Uppsala University,Karolinska Institutet (SE),Uppsala University (SE)
Magnusson, Patrik K E (author)
Karolinska Institutet,Department of Economics, Stockholm School of Economics, Stockholm, Sweden,Karolinska Institutet (SE)
Lindgren, Cecilia M (author)
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA,University of Oxford (GB)
Morris, Andrew P (author)
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Department of Biostatistics, University of Liverpool, Liverpool, UK,University of Oxford (GB)
Cesarini, David (author)
Center for Experimental Social Science, New York University, New York, NY 10012, USA
Johannesson, Magnus (author)
Stockholm School of Economics,Handelshögskolan i Stockholm
Tiensuu Janson, Eva (author)
Uppsala universitet,Endokrin Onkologi,Uppsala University,Uppsala University (SE)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University
Pedersen, Nancy L (author)
Karolinska Institutet
Ingelsson, Erik (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University,Karolinska Institutet (SE)
Forsberg, Lars A. (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
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 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2015
2015
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
Related links:
http://www.ncbi.nlm....
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https://europepmc.or...
https://urn.kb.se/re...
https://doi.org/10.1...
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http://kipublication...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

Subject headings

NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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