- Merritt, Eleanor A., et al.
Facile synthesis of Koser's reagent and derivatives from iodine or aryl iodides
Ingår i: Journal of Organic Chemistry. - 0022-3263. ; 75:21, s. 7416-7419
- The first one-pot synthesis of neutral and electron-rich [hydroxy(tosyloxy)iodo]arenes (HTIBs) from iodine and arenes is presented, thereby avoiding the need for expensive iodine(III) precursors. A large set of HTIBs, including a polyfluorinated analogue, can be obtained from the corresponding aryl iodide under the same conditions. The reaction proceeds under mild conditions, without excess reagents, and is fast and high-yielding. Together, the two presented routes give access to a wide range of HTIBs, which are useful reagents in a variety of synthetic transformations.