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Polymorphisms in th...
Polymorphisms in the genes of the urokinase plasminogen activation system in relation to colorectal cancer
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Försti, A (författare)
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Lei, H (författare)
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- Tavelin, Björn (författare)
- Norrlands University Hospital
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visa fler...
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- Enquist, K (författare)
- Umeå universitet,Näringsforskning
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- Palmqvist, Richard (författare)
- Umeå universitet,Patologi
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Altieri, A (författare)
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning
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Hemminki, K (författare)
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- Lenner, Per (författare)
- Norrlands University Hospital
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(creator_code:org_t)
- Oxford University Press, 2007
- 2007
- Engelska.
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Ingår i: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 18:12, s. 1990-1994
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Extracellular matrix degradation, mediated by the urokinase plasminogen activation (uPA) system, is a critical step in tumor invasion and metastasis. High tumor levels of uPA and its inhibitor PAI-1 have been correlated with poor cancer prognosis. We examined four single nucleotide polymorphisms (SNPs) with a potential effect on expression of genes in the uPA system for their role in colorectal cancer susceptibility and prognosis.Patients and methods: We genotyped the SNPs in 308 Swedish incident colorectal cancer patients with up to 16 years of follow-up and in 585 age- and sex-matched controls. We evaluated the associations between genotypes and colorectal cancer and Dukes' stage. Survival probabilities were compared between different subgroups.Results: Patients with PAI-1 –675 5G/5G genotype had better survival than patients with 4G/4G or 4G/5G genotypes when they had Dukes' stage A or B tumors (P = 0.023 and P = 0.015, respectively). No statistically significant association was observed between the SNPs and the risk of colorectal cancer or Dukes' stage.Conclusions: Our results suggest a role for the PAI-1 genotype in colorectal cancer prognosis, but further studies are needed to evaluate the impact of our finding in the clinic.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- colorectal cancer
- PAI-1
- prognostic biomarker
- single nucleotide polymorphism
- uPA system
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Försti, A
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Lei, H
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Tavelin, Björn
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Enquist, K
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Palmqvist, Richa ...
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Altieri, A
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visa fler...
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Hallmans, Göran, ...
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Hemminki, K
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Lenner, Per
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Annals of Oncolo ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet