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Do other cardiovasc...
Do other cardiovascular risk factors influence the impact of age on the association between blood pressure and mortality? : The MORGAM Project
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Vishram, Julie K. K. (author)
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Borglykke, Anders (author)
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Andreasen, Anne H. (author)
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Jeppesen, Jorgen (author)
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Ibsen, Hans (author)
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Jorgensen, Torben (author)
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Broda, Grazyna (author)
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Palmieri, Luigi (author)
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Giampaoli, Simona (author)
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Donfrancesco, Chiara (author)
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Kee, Frank (author)
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Mancia, Giuseppe (author)
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Cesana, Giancarlo (author)
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Kuulasmaa, Kari (author)
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Salomaa, Veikko (author)
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Sans, Susana (author)
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Ferrieres, Jean (author)
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Tamosiunas, Abdonas (author)
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi,Heart Centre
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Mcelduff, Patrick (author)
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Arveiler, Dominique (author)
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Pajak, Andrzej (author)
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Olsen, Michael H. (author)
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(creator_code:org_t)
- Ovid Technologies, 2014
- 2014
- English.
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In: Journal of Hypertension. - : Ovid Technologies. - 0263-6352 .- 1473-5598. ; 32:5, s. 1025-1033
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To investigate age-related shifts in the relative importance of SBP and DBP as predictors of cardiovascular mortality and all-cause mortality and whether these relations are influenced by other cardiovascular risk factors. Methods: Using 42 cohorts from the MORGAM Project with baseline between 1982 and 1997, 85 772 apparently healthy Europeans and Australians aged 19-78 years were included. During 13.3 years of follow-up, 9.2% died (of whom 7.2% died due to stroke and 21.1% due to coronary heart disease, CHD). Results: Mortality risk was analyzed using hazard ratios per 10-mmHg/5-mmHg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, SBP and DBP were analyzed separately for blood pressure (BP) values above and below a cut-point wherein mortality risk was the lowest. For the total population, significantly positive associations were found between stroke mortality and SBP [hazard ratio = 1.19 (1.13-1.25)] and DBP at least 78 mmHg [hazard ratio = 1.08 (1.02-1.14)], CHD mortality and SBP at least 116 mmHg [1.20 (1.16-1.24)], and all-cause mortality and SBP at least 120 mmHg [1.09 (1.08-1.11)] and DBP at least 82 mmHg [1.03 (1.02-1.05)]. BP values below the cut-points were inversely related to mortality risk. Taking into account the age x BP interaction, there was a gradual shift from DBP (19-26 years) to both DBP and SBP (27-62 years) and to SBP (63-78 years) as risk factors for stroke mortality and all-cause mortality, but not CHD mortality. The age at which the importance of SBP exceeded DBP was for stroke mortality influenced by sex, cholesterol, and country risk. Conclusion: Age-related shifts to the superiority of SBP exist for stroke mortality and all-cause mortality, and for stroke mortality was this shift influenced by other cardiovascular risk factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- blood pressure
- mortality
- risk factors
- age
- epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vishram, Julie K ...
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Borglykke, Ander ...
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Andreasen, Anne ...
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Jeppesen, Jorgen
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Ibsen, Hans
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Jorgensen, Torbe ...
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show more...
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Broda, Grazyna
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Palmieri, Luigi
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Giampaoli, Simon ...
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Donfrancesco, Ch ...
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Kee, Frank
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Mancia, Giuseppe
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Cesana, Giancarl ...
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Kuulasmaa, Kari
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Salomaa, Veikko
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Sans, Susana
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Ferrieres, Jean
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Tamosiunas, Abdo ...
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Söderberg, Stefa ...
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Mcelduff, Patric ...
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Arveiler, Domini ...
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Pajak, Andrzej
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Olsen, Michael H ...
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MEDICAL AND HEAL ...
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Umeå University