Search: onr:"swepub:oai:DiVA.org:umu-96832"
> Medical and Health Sciences >
Impact of Age and G...
Impact of Age and Gender on the Prevalence and Prognostic Importance of the Metabolic Syndrome and Its Components in Europeans. The MORGAM Prospective Cohort Project
-
Vishram, Julie K. K. (author)
-
Borglykke, Anders (author)
-
Andreasen, Anne H. (author)
-
show more...
-
Jeppesen, Jorgen (author)
-
Ibsen, Hans (author)
-
Jorgensen, Torben (author)
-
Palmieri, Luigi (author)
-
Giampaoli, Simona (author)
-
Donfrancesco, Chiara (author)
-
Kee, Frank (author)
-
Mancia, Giuseppe (author)
-
Cesana, Giancarlo (author)
-
Kuulasmaa, Kari (author)
-
Salomaa, Veikko (author)
-
Sans, Susana (author)
-
Ferrieres, Jean (author)
-
Dallongeville, Jean (author)
-
- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
-
Arveiler, Dominique (author)
-
Wagner, Aline (author)
-
Tunstall-Pedoe, Hugh (author)
-
Drygas, Wojciech (author)
-
Olsen, Michael H. (author)
-
show less...
-
(creator_code:org_t)
- 2014-09-22
- 2014
- English.
-
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:9, s. e107294-
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://journals.plo...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS). Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19-78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5. Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P<0.0001); with a 5-fold increase in women from ages 19-39 years to 60-78 years (7.4%/7.6% to 35.4%/37.6% for IDF/NCEP-ATPIII) and a 2-fold increase in men (5.3%/10.5% to 11.5%/21.8%). Using multivariate-adjusted Cox regressions, the associations between MetS and all three CVD events were significant (P<0.0001). For IDF/NCEP-ATPIII in men and women, hazard ratio (HR) for CHD was 1.60/1.62 and 1.93/2.03, for CVD mortality 1.73/1.65 and 1.77/2.06, and for stroke 1.51/1.53 and 1.58/1.77. Whereas in men the HRs for CVD events were independent of age (MetS*age, P>0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS*age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS*age, P>0.05). Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
PLOS ONE
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Vishram, Julie K ...
-
Borglykke, Ander ...
-
Andreasen, Anne ...
-
Jeppesen, Jorgen
-
Ibsen, Hans
-
Jorgensen, Torbe ...
-
show more...
-
Palmieri, Luigi
-
Giampaoli, Simon ...
-
Donfrancesco, Ch ...
-
Kee, Frank
-
Mancia, Giuseppe
-
Cesana, Giancarl ...
-
Kuulasmaa, Kari
-
Salomaa, Veikko
-
Sans, Susana
-
Ferrieres, Jean
-
Dallongeville, J ...
-
Söderberg, Stefa ...
-
Arveiler, Domini ...
-
Wagner, Aline
-
Tunstall-Pedoe, ...
-
Drygas, Wojciech
-
Olsen, Michael H ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
PLOS ONE
- By the university
-
Umeå University