- Andreasson, Håkan, et al.
Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein
Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 32:4, s. 1443-1448
- <p><strong>Aim:</strong></p><p>The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.</p><p><strong>Materials and Methods:</strong></p><p>Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.</p><p><strong>Results:</strong></p><p>The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).</p><p><strong>Conclusion:</strong></p><p>The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.</p>